SERTAD3 and TXN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SERTAD3	TXN
Description		SERTA domain containing 3	thioredoxin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	RNA Binding Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Protein-disulfide Reductase Activity Protein Homodimerization Activity Protein-disulfide Reductase [NAD(P)H] Activity
	Biological Process	Regulation Of DNA-templated Transcription Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Cellular Homeostasis Positive Regulation Of DNA Binding Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Detoxification Of Hydrogen Peroxide Response To Nitric Oxide
Pathways			Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection NFE2L2 regulating anti-oxidant/detoxification enzymes
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Otitis media ( 27632927) Otitis media (chronic) ( 27632927) Otitis media (recurrent) ( 27632927)	Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		43 interacting genes: ANKRD11 BEX2 BFSP2 C1orf216 CCNC CENPP CREBBP CTNNAL1 DPPA3 FAAP20 FBXO44 FCHSD2 GTPBP3 HGS IL16 IMP3 KANK2 KLHL42 KPNA2 MBD3 MED25 MSGN1 NDN NPPB P4HA3 PICK1 PKN1 PRKAA2 RPA2 RTP5 SMARCD1 SNRPB SPG11 SUOX TASOR2 TLE5 TNPO2 TPRX1 TRAPPC6A TXN UBL5 USHBP1 ZGPAT	43 interacting genes: ACTN1 ACTN4 ANKRD11 APEX1 C1QA C4BPA CDKN1A CEBPA CFP COL1A1 COPS5 DDIT4L DNAJA1 DYNLT1 EGFR ERBB2 ERBB3 ERBB4 FNDC3B FST GFER GPRASP2 MAP3K5 MLH1 MRFAP1 MYD88 NCF4 NFE2 NFKB1 NIF3L1 NR3C1 NUP62 PTEN SERTAD3 SIAH1 SPG21 SRPK2 TEX13A TP53 TRAF2 TXNIP UCHL5 VIM
Entrez ID		29946	7295
HPRD ID		15327	01761
Ensembl ID		ENSG00000167565	ENSG00000136810
Uniprot IDs		Q9UJW9	H9ZYJ2 P10599
PDB IDs			1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Response To Epidermal Growth Factor Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Developmental Process Regulation Of Gene Expression ERBB2 Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Response To Stress ERBB Signaling Pathway Cytoplasm Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Cell Differentiation Cellular Response To Epidermal Growth Factor Stimulus ERBB3:ERBB2 Complex Positive Regulation Of Programmed Cell Death Glial Cell Differentiation Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signaling Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cellular Senescence Programmed Necrotic Cell Death Positive Regulation Of MiRNA Metabolic Process
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