GYPB and REEP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GYPB	REEP4
Description		glycophorin B (MNS blood group)	receptor accessory protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Ankyrin-1 Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Microtubule Cytoplasmic Microtubule Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding
	Biological Process		Nuclear Envelope Organization Mitotic Nuclear Membrane Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization
Pathways		Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Severe malaria ( 26416757) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)	Frailty index ( 34431594) Hypertriglyceridemia ( 23505323)
Interacting Genes		5 interacting genes: HSD17B13 REEP4 RHAG S1PR3 UBQLN1	101 interacting genes: AGPAT4 ARLN BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 NINJ2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM14B TMEM167B TMEM18 TMEM19 TMEM208 TMEM229B TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VMA12 VTI1B YIF1A YIPF4 YIPF6
Entrez ID		2994	80346
HPRD ID		00201	09864
Ensembl ID		ENSG00000250361	ENSG00000168476
Uniprot IDs		P06028	E5RGS2 Q9H6H4
PDB IDs		8CRT 8CS9 8CSL
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Establishment Of Endothelial Barrier Leak Channel Activity Methylammonium Transmembrane Transporter Activity Methylammonium Transport Methylammonium Transmembrane Transport Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Steroid Dehydrogenase Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Sphingosine-1-phosphate Receptor Activity Negative Regulation Of Endothelial Cell Differentiation Ammonium Transmembrane Transport Ammonium Channel Activity Ammonium Homeostasis Ankyrin-1 Complex Mitotic Nuclear Membrane Reassembly Amine Transport Regulation Of Establishment Of Endothelial Barrier Sphingolipid Mediated Signaling Pathway Sphingosine-1-phosphate Receptor Signaling Pathway Carbon Dioxide Transport Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Ankyrin Binding Multicellular Organismal-level Iron Ion Homeostasis One-carbon Compound Transport Bicarbonate Transport Negative Regulation Of Transporter Activity Endoplasmic Reticulum Regulation Of ERAD Pathway Endoplasmic Reticulum Tubular Network Nuclear Membrane Reassembly Nuclear Envelope Organization Endoplasmic Reticulum Tubular Network Organization	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Endomembrane System SNAP Receptor Activity SNARE Complex Protein Binding Establishment Of Protein Localization Organelle Fusion Vesicle Fusion Organelle Membrane Fusion Mitochondrial Outer Membrane Membrane Fusion Membrane Organization Vesicle Fusion With Golgi Apparatus Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Membrane Docking Protein Transport Presynaptic Endosome Membrane Golgi Vesicle Transport Monoatomic Ion Transmembrane Transporter Activity Intracellular Transport Cellular Localization Mitochondrial Membrane Nitric-oxide Synthase Complex Vesicle Organization Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Serine Import Into Mitochondrion Olfactory Receptor Binding Establishment Of Localization In Cell Myelination Axon Ensheathment Nitrite Reductase (NO-forming) Activity Transport Vesicle Golgi Membrane Vesicle Docking Menaquinone Metabolic Process SNARE Binding Golgi Organization Import Into The Mitochondrion Bcl-2 Family Protein Complex Mitochondrial Transport
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