GYPB and S1PR3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GYPB	S1PR3
Description		glycophorin B (MNS blood group)	sphingosine-1-phosphate receptor 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane Ankyrin-1 Complex	Cytoplasm Plasma Membrane Membrane Presynapse
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Integrin Binding Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process		Sphingosine-1-phosphate Receptor Signaling Pathway Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Notch Signaling Pathway Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Establishment Of Endothelial Barrier
Pathways		Cell surface interactions at the vascular wall	G alpha (i) signalling events Lysosphingolipid and LPA receptors Extra-nuclear estrogen signaling
Drugs			Fingolimod
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Severe malaria ( 26416757) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 32888494)	Cardiometabolic and hematological traits ( 27668658) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte percentage of white cells ( 27863252 32888494) Response to statins (LDL cholesterol change) ( 22331829) Spleen volume ( 34128465) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		5 interacting genes: HSD17B13 REEP4 RHAG S1PR3 UBQLN1	6 interacting genes: COMT GNA13 GNAI1 GNAQ GYPB HTR1A
Entrez ID		2994	1903
HPRD ID		00201	03572
Ensembl ID		ENSG00000250361	ENSG00000213694
Uniprot IDs		P06028	Q99500
PDB IDs		8CRT 8CS9 8CSL	7C4S 7EW2 7EW3 7EW4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Establishment Of Endothelial Barrier Leak Channel Activity Methylammonium Transmembrane Transporter Activity Methylammonium Transport Methylammonium Transmembrane Transport Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Steroid Dehydrogenase Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Sphingosine-1-phosphate Receptor Activity Negative Regulation Of Endothelial Cell Differentiation Ammonium Transmembrane Transport Ammonium Channel Activity Ammonium Homeostasis Ankyrin-1 Complex Mitotic Nuclear Membrane Reassembly Amine Transport Regulation Of Establishment Of Endothelial Barrier Sphingolipid Mediated Signaling Pathway Sphingosine-1-phosphate Receptor Signaling Pathway Carbon Dioxide Transport Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Ankyrin Binding Multicellular Organismal-level Iron Ion Homeostasis One-carbon Compound Transport Bicarbonate Transport Negative Regulation Of Transporter Activity Endoplasmic Reticulum Regulation Of ERAD Pathway Endoplasmic Reticulum Tubular Network Nuclear Membrane Reassembly Nuclear Envelope Organization Endoplasmic Reticulum Tubular Network Organization	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding G Protein Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Response To Ketone Response To Prostaglandin E Behavioral Fear Response Exploration Behavior Behavioral Defense Response Response To Alcohol G Protein-coupled Receptor Signaling Pathway Fear Response GTPase Activity GTP Binding Multicellular Organismal Response To Stress Norepinephrine Secretion Catechol O-methyltransferase Activity Phenol-containing Compound Metabolic Process Plasma Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Neuropeptide Signaling Pathway Cellular Response To Phosphate Starvation D5 Dopamine Receptor Binding Detection Of Abiotic Stimulus Response To Hormone D2 Dopamine Receptor Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Habituation Mastication Renal Sodium Excretion Renal Albumin Absorption Renin Secretion Into Blood Stream Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Receptor-receptor Interaction Regulation Of Blood Pressure Cerebellar Cortex Morphogenesis Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Serotonin Secretion Response To Lipid Dopamine Secretion Positive Regulation Of Protein Localization To Cell Cortex
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