GMPPA and BTC

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GMPPA	BTC
Gene Name		GDP-mannose pyrophosphorylase A	betacellulin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Nucleotidyltransferase Activity	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process GDP-mannose Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Urine Volume Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Synthesis of GDP-mannose Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Nuclear signaling by ERBB4 SHC1 events in ERBB4 signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BTC CDR2 CRP GMPPB LSM8	6 interactors: EGFR ERBB2 ERBB4 GMPPA KRT31 MMP9
Entrez ID		29926	685
HPRD ID		13588	02643
Ensembl ID		ENSG00000144591
Uniprot IDs		Q96IJ6	P35070
PDB IDs			1IOX 1IP0
Enriched GO Terms of Interacting Partners?			Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Fibroblast Growth Factor Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Peptidyl-amino Acid Modification Neuron Differentiation Immune Response-regulating Cell Surface Receptor Signaling Pathway Axon Guidance Locomotion Positive Regulation Of MAPK Cascade Immune Response-regulating Signaling Pathway Positive Regulation Of Kinase Activity Axonogenesis Movement Of Cell Or Subcellular Component Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transferase Activity Generation Of Neurons Alkanesulfonate Metabolic Process Cardiac Muscle Tissue Regeneration Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Response To Growth Factor Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Neurogenesis Regulation Of MAPK Cascade Regulation Of Cell Motility Neuron Projection Morphogenesis Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Locomotion Cell Development Regulation Of Cellular Component Movement Central Nervous System Morphogenesis Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling
Tagcloud ?			1000mg 100mg 300mg aes already arm biliary btcs centers endpoint endpoints favored gemcitabine infused intravenously italy m2 monotherapy multicenter nct00753675 orr pfs placebo plus reporting tolerability v vandetanib worsening
Tagcloud (Difference) ?			1000mg 100mg 300mg aes already arm biliary btcs centers endpoint endpoints favored gemcitabine infused intravenously italy m2 monotherapy multicenter nct00753675 orr pfs placebo plus reporting tolerability v vandetanib worsening
Tagcloud (Intersection) ?