GMPPA and BTC

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		GMPPA	BTC
Description		GDP-mannose pyrophosphorylase A	betacellulin
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome GDP-mannose Pyrophosphorylase Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Mannose-1-phosphate Guanylyltransferase (GTP) Activity Enzyme Inhibitor Activity Protein Binding Transferase Activity Enzyme Binding Molecular Sensor Activity	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Receptor Ligand Activity
	Biological Process	Protein Glycosylation Glycoprotein Metabolic Process GDP-mannose Biosynthetic Process Negative Regulation Of Biosynthetic Process GDP-mannose Metabolic Process Telencephalon Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Phosphate Metabolic Process Muscle Organ Morphogenesis Cognition Neuromuscular Process Neuron Apoptotic Process Skeletal Muscle Organ Development Motor Behavior Negative Regulation Of Small Molecule Metabolic Process	Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Urine Volume ERBB2-EGFR Signaling Pathway ERBB4-ERBB4 Signaling Pathway Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Division Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process
Pathways		Synthesis of GDP-mannose	Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS			Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561 33909500) Diverticular disease ( 30177863) Electroencephalogram traits ( 25387704) FEV1 ( 30804560) Haemorrhoidal disease ( 33888516) Lung function (FEV1/FVC) ( 30804560)
Interacting Genes		10 interacting genes: AKT1 BTC CDR2 CRP DCUN1D1 GMPPB GPKOW LSM8 NCK1 ZNF688	11 interacting genes: DNAJC5 EGFR ERBB2 ERBB4 GMPPA KPRP KRT31 KRTAP1-3 MMP9 SGTA SGTB
Entrez ID		29926	685
HPRD ID		13588	02643
Ensembl ID		ENSG00000144591	ENSG00000174808
Uniprot IDs		A0A384MDS7 Q96IJ6	A0A0S2Z3I5 A0A0S2Z437 P35070
PDB IDs		7D72 7D73 7D74	1IOX 1IP0 8U4J 8U4K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of PERK-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response	ERBB2 Signaling Pathway TRC Complex Epidermal Growth Factor Receptor Activity Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor ERBB2-ERBB4 Signaling Pathway Basal Plasma Membrane Localization Within Membrane ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Phosphorylation ERBB Signaling Pathway Neuromuscular Junction ERBB4 Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Response To UV-A Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Modification Process Protein Tyrosine Kinase Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Epidermis Development Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Programmed Cell Death Protein Targeting To ER Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Establishment Of Protein Localization To Endoplasmic Reticulum Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Establishment Of Protein Localization To Membrane Basolateral Plasma Membrane Receptor Localization To Synapse Positive Regulation Of Growth Peptidyl-tyrosine Phosphorylation Regulation Of Protein Modification Process Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Growth Factor Stimulus Multivesicular Body, Internal Vesicle Lumen Protein Localization To Synapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Structural Constituent Of Skin Epidermis Regulation Of ERK1 And ERK2 Cascade Protein Insertion Into Membrane
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