GUCY2F and GLA

		GUCY2F	GLA
Description		guanylate cyclase 2F, retinal	galactosidase alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Outer Membrane Plasma Membrane Membrane Cell Projection Photoreceptor Disc Membrane Rod Photoreceptor Outer Segment	Extracellular Region Cytoplasm Lysosome Golgi Apparatus Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Signaling Receptor Binding Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity
	Biological Process	CGMP Biosynthetic Process Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Cyclic Nucleotide Biosynthetic Process CGMP-mediated Signaling Regulation Of Opsin-mediated Signaling Pathway Intracellular Signal Transduction Detection Of Light Stimulus Involved In Visual Perception	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Glycoside Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Glycosylceramide Catabolic Process Glycosphingolipid Catabolic Process Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Neutrophil degranulation Glycosphingolipid catabolism
Drugs			Migalastat
Diseases			Fabry disease
GWAS
Interacting Genes		1 interacting genes: GUCA1B	3 interacting genes: OGT TERT UBC
Entrez ID		2986	2717
HPRD ID		02078	02357
Ensembl ID		ENSG00000101890	ENSG00000102393
Uniprot IDs		P51841	A0A3B3IUC4 A0A6Q8PHD1 P06280 Q53Y83
PDB IDs			1R46 1R47 3GXN 3GXP 3GXT 3HG2 3HG3 3HG4 3HG5 3LX9 3LXA 3LXB 3LXC 3S5Y 3S5Z 3TV8 4NXS 6IBK 6IBM 6IBR 6IBT 8K7D 8K7E 8K7F 8K7G 8K7H 8K7I 8K7J 8K7K 8K7L 9AVS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nitric-oxide Synthase Activity Alpha-galactosidase Activity Guanylate Cyclase Regulator Activity Glycosylceramide Catabolic Process Regulation Of Nitric-oxide Synthase Activity Glycoside Catabolic Process Cone Photoreceptor Outer Segment Calcium Sensitive Guanylate Cyclase Activator Activity Negative Regulation Of Oxidoreductase Activity Glycosylceramide Metabolic Process Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Ceramide Catabolic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Oxidoreductase Activity Photoreceptor Disc Membrane Receptor Guanylyl Cyclase Signaling Pathway Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Sphingolipid Catabolic Process Phototransduction Membrane Lipid Catabolic Process Oligosaccharide Metabolic Process Glycosphingolipid Metabolic Process Photoreceptor Inner Segment Detection Of Light Stimulus Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Photoreceptor Outer Segment Hydrolase Activity, Acting On Glycosyl Bonds Body Fluid Secretion Glycolipid Metabolic Process Ceramide Metabolic Process Azurophil Granule Lumen Lysosomal Lumen Detection Of Abiotic Stimulus Sphingolipid Metabolic Process
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