SAP30BP and DHX8

Number of citations of the paper that reports this interaction (PubMedID 34079125)
0

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		SAP30BP	DHX8
Description		SAP30 binding protein	DEAH-box helicase 8
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Body U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On RNA Hydrolase Activity ATP Hydrolysis Activity Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Response To Virus	MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing
Pathways		NoRC negatively regulates rRNA expression	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Rotator cuff tears ( 26350878)	HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
Interacting Genes		25 interacting genes: DHX8 FHL2 FHL3 FRA10AC1 GOLGA2 GSK3B MLX OGT PRKAR1B PUF60 RBM17 RBM39 RPS6KA6 SAP30 SNCA SUPT5H TFIP11 THAP1 THOC1 U2AF2 USP7 WDR77 WDR83 ZNF212 ZNF408	12 interacting genes: BUB1B LUC7L2 MFAP1 PRPF38A PRPF40A RBM7 RBMX2 SAP30BP SRPK1 SRPK2 THOC1 UBC
Entrez ID		29115	1659
HPRD ID		17094	02672
Ensembl ID		ENSG00000161526	ENSG00000067596
Uniprot IDs		Q9UHR5	B7Z8F4 F5H658 K7END7 Q05CV4 Q14562 Q86YB2
PDB IDs			2EQS 3I4U 5MQF 5XJC 6HYS 6HYT 6HYU 6ICZ 6QDV 7W59 7W5A 7W5B 8C6J 9FMD
Enriched GO Terms of Interacting Partners?		RNA Splicing MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing, Via Transesterification Reactions Nucleus MRNA Metabolic Process Nucleoplasm RNA Metabolic Process RNA Processing Spliceosomal Complex Regulation Of Nucleobase-containing Compound Metabolic Process TOR Signaling Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Catabolic Process Macromolecule Metabolic Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Processing Regulation Of Primary Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Nucleic Acid Binding Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Autophagy Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Kinase A Catalytic Subunit Binding Catalytic Step 2 Spliceosome Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Macromolecule Metabolic Process Sin3-type Complex Negative Regulation Of Autophagy Identical Protein Binding Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Negative Regulation Of Stem Cell Population Maintenance Alternative MRNA Splicing, Via Spliceosome	RNA Binding RNA Splicing MRNA Processing MRNA Metabolic Process RNA Processing RNA Metabolic Process Nucleoplasm Spliceosomal Complex Assembly U2-type Precatalytic Spliceosome Nucleus MRNA Splicing, Via Spliceosome Nuclear Speck Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome U2-type Prespliceosome Nucleobase-containing Compound Metabolic Process U1 SnRNP Precatalytic Spliceosome Nuclear Matrix Regulation Of MRNA Processing Positive Regulation Of Viral Genome Replication 14-3-3 Protein Binding Spliceosomal Complex Regulation Of RNA Splicing Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Macromolecule Metabolic Process Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Regulation Of MRNA Metabolic Process Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Mitotic Checkpoint Complex Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Viral Life Cycle Nuclear Speck Organization THO Complex SnRNA Catabolic Process Regulation Of Viral Process THO Complex Part Of Transcription Export Complex Protein Kinase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Metaphase/anaphase Transition Of Cell Cycle R-loop Processing Meiotic Sister Chromatid Cohesion Kinase Activity Transcription Export Complex SnRNA Binding
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