TBK1 and SCN7A

		TBK1	SCN7A
Description		TANK binding kinase 1	sodium voltage-gated channel alpha subunit 7
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Serine/threonine Protein Kinase Complex	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Glial Cell Projection
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Identical Protein Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Serine Kinase Activity	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Transmembrane Transporter Binding Osmolarity-sensing Monoatomic Cation Channel Activity
	Biological Process	Cytoplasmic Translation Activation Of Innate Immune Response Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Phosphorylation Protein Import Into Nucleus Inflammatory Response Canonical NF-kappaB Signal Transduction MRNA Transcription Response To Virus Regulation Of Gene Expression Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Macroautophagy Positive Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway TORC1 Signaling TORC2 Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Dendritic Cell Proliferation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Defense Response To Gram-positive Bacterium Defense Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway T Follicular Helper Cell Differentiation Defense Response To Other Organism Antiviral Innate Immune Response CGAS/STING Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling	Monoatomic Ion Transport Sodium Ion Transport Osmosensory Signaling Pathway Response To Bacterium Cellular Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Homeostasis Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction
Pathways		IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN PINK1-PRKN Mediated Mitophagy TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling Interleukin-37 signaling TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Potential therapeutics for SARS SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Fostamatinib	Ranolazine Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Chloroprocaine Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Amyotrophic lateral sclerosis ( 27455348 29566793) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lung adenocarcinoma ( 28604730) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Amyotrophic lateral sclerosis ( 19451621) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		47 interacting genes: AGO2 APP ATG9A AZI2 CDC20 CDC37 CDC42BPG CRTC1 CYLD FZR1 HSP90AA1 HSP90AB1 IKBKB IKBKG IRF3 IRF5 IRF7 LMO7 MAVS MBP MIB2 MTPAP NCK1 NFKBIA PROS1 PTPRD RELA RIPK1 RNF128 RPS6KB1 SIKE1 SMCR8 SMURF1 STX11 TANK TICAM1 TNIP1 TRAF2 TRAF3 TRAF3IP2 TRAF5 TRIM21 TXLNG UBC UBQLN2 VHL XIAP
Entrez ID		29110	6332
HPRD ID		05322	08355
Ensembl ID		ENSG00000183735	ENSG00000136546
Uniprot IDs		Q9UHD2	Q01118
PDB IDs		4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ 5EOA 5EOF 5EP6 5W5V 6BNY 6BOD 6BOE 6CQ0 6CQ4 6CQ5 6NT9 6O8B 6RSR 6RST 6RSU	7TJ8 7TJ9
Enriched GO Terms of Interacting Partners?		Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Metabolic Process Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Regulation Of Immune Response Regulation Of Innate Immune Response Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Activation Of Immune Response Immune Response-activating Signaling Pathway Defense Response Regulation Of Protein Metabolic Process Positive Regulation Of Defense Response Positive Regulation Of Innate Immune Response Regulation Of Cell Communication Positive Regulation Of Type I Interferon Production Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Interferon-beta Production Response To Virus Tumor Necrosis Factor-mediated Signaling Pathway Response To External Biotic Stimulus Cytosol Immune Response-regulating Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Regulation Of Intracellular Signal Transduction Response To Other Organism Regulation Of Immune System Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Immune Response Signaling Adaptor Activity Cytoplasm Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cytokine Production Protein Ubiquitination	T Cell Differentiation Involved In Immune Response Regulation Of TORC2 Signaling Peptidyl-serine Phosphorylation Cell Surface Toll-like Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression TORC2 Signaling Positive Regulation Of Xenophagy Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway T-helper Cell Differentiation CGAS/STING Signaling Pathway Positive Regulation Of Interferon-alpha Production Regulation Of Type I Interferon-mediated Signaling Pathway Dendritic Cell Proliferation Peptidyl-threonine Phosphorylation Serine/threonine Protein Kinase Complex T Follicular Helper Cell Differentiation Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Phosphoprotein Binding Negative Regulation Of Type I Interferon Production Positive Regulation Of TORC2 Signaling T Cell Activation Involved In Immune Response Type I Interferon-mediated Signaling Pathway MRNA Transcription Alpha-beta T Cell Differentiation Positive Regulation Of TORC1 Signaling Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Translational Initiation Negative Regulation Of TORC1 Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway TORC1 Signaling Regulation Of Interferon-beta Production Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Antiviral Innate Immune Response Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of TOR Signaling TOR Signaling Protein Phosphatase Binding Positive Regulation Of Macroautophagy Regulation Of TORC1 Signaling Alpha-beta T Cell Activation
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