SCN7A

Description		sodium voltage-gated channel alpha subunit 7
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Membrane Glial Cell Projection
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Sodium Channel Activity Monoatomic Cation Channel Activity Sodium Channel Activity Protein Binding Transmembrane Transporter Binding Osmolarity-sensing Monoatomic Cation Channel Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Osmosensory Signaling Pathway Response To Bacterium Cellular Homeostasis Sodium Ion Transmembrane Transport Sodium Ion Homeostasis Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Ranolazine Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Cocaine Promethazine Chloroprocaine Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Bioallethrin Fish oil
Diseases
GWAS		Amyotrophic lateral sclerosis ( 19451621) Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Novel Interacting Genes		1 novel interacting genes: TBK1
Interacting Genes
Entrez ID		6332
HPRD ID		08355
Ensembl ID		ENSG00000136546
Uniprot IDs		Q01118
PDB IDs		7TJ8 7TJ9
Enriched GO Terms of Interacting Partners?		T Cell Differentiation Involved In Immune Response Regulation Of TORC2 Signaling Peptidyl-serine Phosphorylation Cell Surface Toll-like Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression TORC2 Signaling Positive Regulation Of Xenophagy Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway T-helper Cell Differentiation CGAS/STING Signaling Pathway Positive Regulation Of Interferon-alpha Production Regulation Of Type I Interferon-mediated Signaling Pathway Dendritic Cell Proliferation Peptidyl-threonine Phosphorylation Serine/threonine Protein Kinase Complex T Follicular Helper Cell Differentiation Positive Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Phosphoprotein Binding Negative Regulation Of Type I Interferon Production Positive Regulation Of TORC2 Signaling T Cell Activation Involved In Immune Response Type I Interferon-mediated Signaling Pathway MRNA Transcription Alpha-beta T Cell Differentiation Positive Regulation Of TORC1 Signaling Positive Regulation Of Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Translational Initiation Negative Regulation Of TORC1 Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway TORC1 Signaling Regulation Of Interferon-beta Production Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Antiviral Innate Immune Response Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of TOR Signaling TOR Signaling Protein Phosphatase Binding Positive Regulation Of Macroautophagy Regulation Of TORC1 Signaling Alpha-beta T Cell Activation
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