LGALSL and LHX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LGALSL	LHX2
Description		galectin like	LIM homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus
	Molecular Function	Protein Binding Carbohydrate Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process		Neural Tube Closure Hair Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axon Guidance Brain Development Mesoderm Development Dorsal/ventral Pattern Formation Telencephalon Development Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neurogenesis Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation
Pathways			Regulation of expression of SLITs and ROBOs Expression and translocation of olfactory receptors
Drugs
Diseases
GWAS			Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)
Interacting Genes		6 interacting genes: ACD DDIT4L LHX2 MAD1L1 TERF2IP TINF2	30 interacting genes: ANKS1A ARHGAP32 BEND2 CITED2 DNMT3L FLYWCH1 HOMER3 HOXC8 KHK LGALSL LNX1 LONRF1 MORF4L1 MORN3 MSX1 NFIA NFIB NFIC OSMR PAX6 POU4F2 PPIL1 RLIM TCEANC TCP11L1 TLK1 TRAPPC2L UBTFL1 ZFP42 ZNF511
Entrez ID		29094	9355
HPRD ID		13708	04786
Ensembl ID		ENSG00000119862	ENSG00000106689
Uniprot IDs		Q3ZCW2	B3KNJ5 P50458
PDB IDs		2JJ6 3B9C
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Telomere Assembly Regulation Of Chromosome Organization Positive Regulation Of Telomere Maintenance Protection From Non-homologous End Joining At Telomere Telomere Maintenance Protein Localization To Chromosome Regulation Of Telomere Maintenance Telomere Maintenance In Response To DNA Damage Telomere Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Chromosome, Telomeric Region RNA-templated DNA Biosynthetic Process Protein Localization To Organelle Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Chromosome Negative Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Chromosome Organization Nuclear Body MAD1 Complex Regulation Of DNA Biosynthetic Process Positive Regulation Of Cellular Component Organization DNA Biosynthetic Process Regulation Of Organelle Organization Mitotic Spindle Assembly Checkpoint MAD1-MAD2 Complex Perinucleolar Chromocenter Regulation Of DNA Metabolic Process Negative Regulation Of DNA Recombination At Telomere Deactivation Of Mitotic Spindle Assembly Checkpoint Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Kinetochore Binding Telencephalon Regionalization DNA Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Maintenance Of Epithelial Cell Apical/basal Polarity	Glial Cell Fate Specification Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Retina Development In Camera-type Eye Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Animal Organ Development Regulation Of Transcription By RNA Polymerase II DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Gene Expression Forebrain Development Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Exit From Mitosis Embryonic Camera-type Eye Morphogenesis Negative Regulation Of Biosynthetic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Synapse Maturation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription BMP Signaling Pathway Response To Wounding Sequence-specific Double-stranded DNA Binding Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cell Fate Specification Regulation Of Primary Metabolic Process Generation Of Neurons Regulation Of Macromolecule Metabolic Process Neural Precursor Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex DNA-templated Transcription Histone Acetyltransferase Binding Embryonic Eye Morphogenesis
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