ZDHHC22 and LDLRAD4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZDHHC22	LDLRAD4
Description		zDHHC palmitoyltransferase 22	low density lipoprotein receptor class A domain containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane	Golgi Membrane Endosome Membrane Early Endosome Membrane
	Molecular Function	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity	Protein Binding R-SMAD Binding
	Biological Process	Protein Targeting To Membrane Protein Palmitoylation Protein Localization To Plasma Membrane	Negative Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of SMAD Protein Signal Transduction
Pathways
Drugs
Diseases
GWAS		Cerebrospinal P-tau181p levels ( 28247064) Large artery stroke ( 24262325) Smoking status (ever vs never smokers) ( 30643258) Sweet taste preference ( 32572145)	Adverse response to drug ( 30420678) Depressive symptom improvement ( 30468137) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (functional units) ( 27694959) Macular thickness ( 30535121) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		14 interacting genes: CD79A CLEC4D CLSTN3 CREB3L1 FCRL2 FNDC9 GPX8 LDLRAD4 PVR RPRM TMEM14B TMEM86B TMEM88 TRIM59	4 interacting genes: GET3 NEDD4 SGTA ZDHHC22
Entrez ID		283576	753
HPRD ID		12655	07358
Ensembl ID		ENSG00000177108	ENSG00000168675
Uniprot IDs		Q8N966	A0A7I2V575 A8K6A9 O15165
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane	Establishment Of Protein Localization To Membrane Tail-anchored Membrane Protein Insertion Into ER Membrane Protein Targeting Protein Insertion Into ER Membrane Establishment Of Protein Localization Cellular Localization Protein Insertion Into Membrane Protein Targeting To Membrane Localization Within Membrane Formation Of Structure Involved In A Symbiotic Process Channel Inhibitor Activity TRC Complex GET Complex Phosphothreonine Residue Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of Protein Catabolic Process BAT3 Complex Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Phosphoserine Residue Binding Beta-2 Adrenergic Receptor Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of ERAD Pathway Sodium Channel Inhibitor Activity Establishment Of Protein Localization To Organelle Potassium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Endocardial Cushion Development Negative Regulation Of Sodium Ion Transport Membrane Insertase Activity Proline-rich Region Binding Receptor Catabolic Process RNA Polymerase Binding Positive Regulation Of ERAD Pathway Protein Palmitoylation Palmitoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Negative Regulation Of Potassium Ion Transmembrane Transport Apicolateral Plasma Membrane Viral Budding Regulation Of ERAD Pathway Antigen Processing And Presentation Of Endogenous Antigen Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Protein Targeting To Lysosome Negative Regulation Of Potassium Ion Transport
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