TRIM59 and OTOL1

		TRIM59	OTOL1
Description		tripartite motif containing 59	otolin 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intraciliary Transport Particle B	Extracellular Region Collagen Trimer
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Calcium Ion Binding Metal Ion Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Host-mediated Suppression Of Symbiont Invasion	Otolith Mineralization Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Bipolar disorder ( 31043756) Eosinophil percentage of white cells ( 32888494) Intrinsic epigenetic age acceleration ( 29374233) Malaria ( 31844061) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Adventurousness ( 30643258) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Aging (time to death) ( 21782286) Alcohol consumption (drinks per week) ( 30643258) Hepcidin/ferritin ratio ( 27846281) Schizophrenia ( 28991256 30285260) Schizophrenia x sex interaction ( 34099189) Type 2 diabetes ( 30130595)
Interacting Genes		29 interacting genes: ANKRD33 BLZF1 CCDC33 CDK5 CLDN4 ECSIT EIF2B1 ESR1 ESR2 KEAP1 KRTAP13-3 MACROH2A1 MEI4 MRPL12 NECAB2 NRM PIN1 PKNOX1 PLLP RASSF3 RHOU SEC22A SNAP47 SYVN1 UBE2J2 UBE2W VTI1B ZDHHC21 ZDHHC22
Entrez ID		286827	131149
HPRD ID		15568	19083
Ensembl ID		ENSG00000213186	ENSG00000182447
Uniprot IDs		Q8IWR1	A6NHN0
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Estrogen Receptor Activity SNAP Receptor Activity Negative Regulation Of Response To Oxidative Stress	Intraciliary Transport Particle B Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Negative Regulation Of Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Protein Ubiquitination Protein Modification By Small Protein Conjugation Intraciliary Anterograde Transport Post-translational Protein Modification Cartilage Development Involved In Endochondral Bone Morphogenesis Negative Regulation Of Keratinocyte Proliferation Host-mediated Suppression Of Symbiont Invasion Regulation Of Non-canonical Wnt Signaling Pathway Spinal Cord Development Endochondral Ossification Keratinocyte Proliferation Neuroepithelial Cell Differentiation Bone Morphogenesis Ciliary Tip Regulation Of Keratinocyte Proliferation Osteoclast Differentiation Intraciliary Transport Non-motile Cilium Assembly Negative Regulation Of Signal Transduction Chondrocyte Differentiation Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Protein Localization To Cilium Limb Development Non-canonical Wnt Signaling Pathway Canonical NF-kappaB Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Connective Tissue Development Bone Development Protein Modification Process Stem Cell Proliferation Smoothened Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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