OTOL1

Description		otolin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer
	Molecular Function	Calcium Ion Binding Metal Ion Binding
	Biological Process	Otolith Mineralization Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Aging (time to death) ( 21782286) Alcohol consumption (drinks per week) ( 30643258) Hepcidin/ferritin ratio ( 27846281) Schizophrenia ( 28991256 30285260) Schizophrenia x sex interaction ( 34099189) Type 2 diabetes ( 30130595)
Novel Interacting Genes		2 novel interacting genes: IFT80 TRIM59
Interacting Genes
Entrez ID		131149
HPRD ID		19083
Ensembl ID		ENSG00000182447
Uniprot IDs		A6NHN0
PDB IDs
Enriched GO Terms of Interacting Partners?		Intraciliary Transport Particle B Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Negative Regulation Of Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Protein Ubiquitination Protein Modification By Small Protein Conjugation Intraciliary Anterograde Transport Post-translational Protein Modification Cartilage Development Involved In Endochondral Bone Morphogenesis Negative Regulation Of Keratinocyte Proliferation Host-mediated Suppression Of Symbiont Invasion Regulation Of Non-canonical Wnt Signaling Pathway Spinal Cord Development Endochondral Ossification Keratinocyte Proliferation Neuroepithelial Cell Differentiation Bone Morphogenesis Ciliary Tip Regulation Of Keratinocyte Proliferation Osteoclast Differentiation Intraciliary Transport Non-motile Cilium Assembly Negative Regulation Of Signal Transduction Chondrocyte Differentiation Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Protein Localization To Cilium Limb Development Non-canonical Wnt Signaling Pathway Canonical NF-kappaB Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Connective Tissue Development Bone Development Protein Modification Process Stem Cell Proliferation Smoothened Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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