SLC31A2 and RAMP1

Number of citations of the paper that reports this interaction (PMID 14722252)
7

Data Source:
BioGRID (pull down)

		SLC31A2	RAMP1
Gene Name		solute carrier family 31 (copper transporter), member 2	receptor (G protein-coupled) activity modifying protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Late Endosome Integral Component Of Plasma Membrane Recycling Endosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Copper Ion Transmembrane Transporter Activity	Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity Coreceptor Activity Calcitonin Receptor Binding
	Biological Process	Copper Ion Transport Cellular Copper Ion Homeostasis Copper Ion Transmembrane Transport Regulation Of Copper Ion Transmembrane Transport	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Pramlintide
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		4 interactors: RAMP1 RAMP2 RAMP3 VKORC1	6 interactors: CALCA CALCR CALCRL IAPP SLC31A2 VIPR1
Entrez ID		1318	10267
HPRD ID		04365	05515
Ensembl ID		ENSG00000136867	ENSG00000132329
Uniprot IDs		O15432 Q53X94	E9PC20 O60894
PDB IDs			2YX8 3N7P 3N7R 3N7S
Enriched GO Terms of Interacting Partners?		Receptor Internalization Receptor Metabolic Process Protein Localization To Plasma Membrane Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Plasma Membrane Organization Calcium Ion Transport Receptor-mediated Endocytosis Protein Localization To Membrane Endomembrane System Organization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Endocytosis Regulation Of CAMP Metabolic Process Response To Estradiol Metal Ion Transport Membrane Organization Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Response To Estrogen Basement Membrane Assembly Cation Transport Positive Regulation Of Protein Glycosylation G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Vitamin K Metabolic Process Angiogenesis Vascular Smooth Muscle Cell Development Ion Transport Regulation Of Protein Glycosylation Positive Regulation Of Vasculogenesis Blood Vessel Morphogenesis Negative Regulation Of Vascular Permeability Protein Localization Peptidyl-glutamic Acid Carboxylation Establishment Of Localization In Cell Response To Steroid Hormone Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Vasculogenesis Positive Regulation Of Glycoprotein Metabolic Process Blood Vessel Development Positive Regulation Of Receptor Recycling Vascular Smooth Muscle Cell Differentiation Vasculature Development Basement Membrane Organization	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Internalization Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Negative Regulation Of Bone Resorption Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Regulation Of Bone Resorption Positive Regulation Of Adenylate Cyclase Activity Regulation Of Bone Remodeling Positive Regulation Of Lyase Activity Receptor-mediated Endocytosis G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Cellular Metal Ion Homeostasis Regulation Of Cyclase Activity Regulation Of Tissue Remodeling Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Sensory Perception Of Pain Feeding Behavior Ion Homeostasis Regulation Of Copper Ion Transmembrane Transport Cellular Response To Sucrose Stimulus Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Endocytosis Cellular Homeostasis Regulation Of Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Cell-cell Signaling Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Inflammatory Response Negative Regulation Of Calcium Ion Transport Into Cytosol Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signal Transduction Positive Regulation Of Macrophage Differentiation Copper Ion Transmembrane Transport G-protein Coupled Receptor Internalization
Tagcloud ?			adenylate autoradiography barrier bbb blockers blue calcitonin cgrp clr cyclase densities evans ganglion glutamate glutamatergic immunofluorescence migraine mk modifying outside pacap penetrant penetration pituitary polypeptide protected rhesus tg trigeminal
Tagcloud (Difference) ?			adenylate autoradiography barrier bbb blockers blue calcitonin cgrp clr cyclase densities evans ganglion glutamate glutamatergic immunofluorescence migraine mk modifying outside pacap penetrant penetration pituitary polypeptide protected rhesus tg trigeminal
Tagcloud (Intersection) ?