SLC31A2 and RAMP1

Number of citations of the paper that reports this interaction (PubMedID 14722252)
0

Data Source:
BioGRID (pull down)

		SLC31A2	RAMP1
Description		solute carrier family 31 member 2	receptor activity modifying protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Recycling Endosome	Plasma Membrane Cell Surface Membrane Receptor Complex CGRP Receptor Complex
	Molecular Function	Copper Ion Transmembrane Transporter Activity Protein Binding	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding
	Biological Process	Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Copper Ion Import Copper Ion Transmembrane Transport Regulation Of Copper Ion Transmembrane Transport	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways			G alpha (s) signalling events Calcitonin-like ligand receptors
Drugs			Pramlintide
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494)	Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)
Interacting Genes		9 interacting genes: BNIP3 F2RL1 GPR35 HTR2B OPRL1 RAMP1 RAMP2 RAMP3 VKORC1	10 interacting genes: CALCA CALCR CALCRL DCLK3 IAPP MAL MS4A13 NKG7 SLC31A2 VIPR1
Entrez ID		1318	10267
HPRD ID		04365	05515
Ensembl ID		ENSG00000136867	ENSG00000132329
Uniprot IDs		O15432 Q53X94	E9PC20 O60894
PDB IDs			2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y 6UMG 6ZHO 6ZIS 7KNT 7KNU 7P0F 7P0I 7TYF 7TYW 8AX5 8AX6 8AX7 9AUC
Enriched GO Terms of Interacting Partners?		Amylin Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Calcitonin Family Receptor Signaling Pathway Adrenomedullin Receptor Activity Adrenomedullin Receptor Complex Amylin Receptor Activity Adrenomedullin Receptor Signaling Pathway Coreceptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Ion Transport Receptor Internalization G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Signal Transduction G-protein Alpha-subunit Binding Positive Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Receptor Complex Positive Regulation Of Protein-containing Complex Disassembly Metal Ion Transport Protein Localization To Cell Periphery Membrane Vascular Process In Circulatory System Regulation Of ERK1 And ERK2 Cascade Monoatomic Cation Transport Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Circulatory System Process Positive Regulation Of Renin Secretion Into Blood Stream Nociceptin Receptor Activity Protein Localization To Membrane Calcitonin Gene-related Peptide Binding Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Cellular Response To Hormone Stimulus Regulation Of Biological Quality Monoatomic Ion Transport Proteinase-activated Receptor Activity Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Adrenomedullin Binding CGRP Receptor Complex Amylin Receptor Complex 3 Peptidyl-glutamic Acid Carboxylation Oxidoreductase Activity, Acting On CH Or CH2 Groups, Disulfide As Acceptor Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia	Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Receptor Activity Amylin Receptor 3 Signaling Pathway Calcitonin Gene-related Peptide Receptor Activity Negative Regulation Of Bone Resorption G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Bone Remodeling Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Transmembrane Signaling Receptor Activity Regulation Of Bone Remodeling Regulation Of CAMP/PKA Signal Transduction Osteoclast Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Amylin Receptor Complex 2 Calcitonin Family Receptor Activity Positive Regulation Of Calcium-mediated Signaling Amylin Receptor Complex 1 Calcitonin Binding Regulation Of Copper Ion Transmembrane Transport Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Sucrose Stimulus Regulation Of Osteoclast Differentiation Receptor Internalization Regulation Of Tissue Remodeling Calcitonin Receptor Binding Amyloid-beta Binding Amylin Receptor Complex 3 G Protein-coupled Receptor Activity Adrenomedullin Binding CGRP Receptor Complex Negative Regulation Of Myeloid Cell Differentiation Regulation Of Calcium-mediated Signaling Amylin Receptor Activity Membrane Raft Polarization Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Hormone Activity
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