SLC31A2 and RAMP2

Number of citations of the paper that reports this interaction (PMID 14722252)
7

Data Source:
BioGRID (pull down)

		SLC31A2	RAMP2
Gene Name		solute carrier family 31 (copper transporter), member 2	receptor (G protein-coupled) activity modifying protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Late Endosome Integral Component Of Plasma Membrane Recycling Endosome	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Cell Surface Receptor Complex
	Molecular Function	Copper Ion Transmembrane Transporter Activity	Protein Binding Protein Transporter Activity Coreceptor Activity
	Biological Process	Copper Ion Transport Cellular Copper Ion Homeostasis Copper Ion Transmembrane Transport Regulation Of Copper Ion Transmembrane Transport	Angiogenesis Vasculogenesis Response To Hypoxia Sprouting Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Heart Development Female Pregnancy Regulation Of Blood Pressure Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Development Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Pramlintide
Diseases
GWAS
Protein-Protein Interactions		4 interactors: RAMP1 RAMP2 RAMP3 VKORC1	5 interactors: CALCA CALCRL IAPP SLC31A2 VIPR1
Entrez ID		1318	10266
HPRD ID		04365	05516
Ensembl ID		ENSG00000136867	ENSG00000131477
Uniprot IDs		O15432 Q53X94	K7EMD3 O60895
PDB IDs			2XVT 3AQE 3AQF
Enriched GO Terms of Interacting Partners?		Receptor Internalization Receptor Metabolic Process Protein Localization To Plasma Membrane Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Plasma Membrane Organization Calcium Ion Transport Receptor-mediated Endocytosis Protein Localization To Membrane Endomembrane System Organization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Endocytosis Regulation Of CAMP Metabolic Process Response To Estradiol Metal Ion Transport Membrane Organization Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Response To Estrogen Basement Membrane Assembly Cation Transport Positive Regulation Of Protein Glycosylation G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Intracellular Transport Vitamin K Metabolic Process Angiogenesis Vascular Smooth Muscle Cell Development Ion Transport Regulation Of Protein Glycosylation Positive Regulation Of Vasculogenesis Blood Vessel Morphogenesis Negative Regulation Of Vascular Permeability Protein Localization Peptidyl-glutamic Acid Carboxylation Establishment Of Localization In Cell Response To Steroid Hormone Positive Regulation Of Glycoprotein Biosynthetic Process Regulation Of Vasculogenesis Positive Regulation Of Glycoprotein Metabolic Process Blood Vessel Development Positive Regulation Of Receptor Recycling Vascular Smooth Muscle Cell Differentiation Vasculature Development Basement Membrane Organization	Negative Regulation Of Bone Resorption G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Regulation Of Bone Resorption Receptor Internalization Regulation Of Bone Remodeling Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Tissue Remodeling Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Feeding Behavior Regulation Of CAMP Metabolic Process Regulation Of Copper Ion Transmembrane Transport Cellular Response To Sucrose Stimulus Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Inflammatory Response Negative Regulation Of Calcium Ion Transport Into Cytosol Receptor-mediated Endocytosis Positive Regulation Of Macrophage Differentiation Copper Ion Transmembrane Transport G-protein Coupled Receptor Internalization Cellular Metal Ion Homeostasis Negative Regulation Of Neurological System Process Monocyte Chemotaxis Negative Regulation Of Smooth Muscle Contraction Cellular Cation Homeostasis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cellular Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Sucrose Endothelial Cell Proliferation Metal Ion Homeostasis Cellular Copper Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Muscle Contraction CAMP Biosynthetic Process Copper Ion Homeostasis Cellular Chemical Homeostasis
Tagcloud ?			abundantly accessory adrenomedullin bioactivities calcitonin ccaat clr evokes exerting glomeruli glut2 illustrating lethality littermates pathophysiological perk ramps reproduce rptecs streptozotocin stz subisoforms takes tubular tubule tubules tun tunicamycin
Tagcloud (Difference) ?			abundantly accessory adrenomedullin bioactivities calcitonin ccaat clr evokes exerting glomeruli glut2 illustrating lethality littermates pathophysiological perk ramps reproduce rptecs streptozotocin stz subisoforms takes tubular tubule tubules tun tunicamycin
Tagcloud (Intersection) ?