FRYL and PRR35

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FRYL	PRR35
Description		FRY like transcription coactivator	proline rich 35
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Cortex Site Of Polarized Growth
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Morphogenesis Neuron Projection Development
Pathways
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Height ( 31562340) Hemoglobin ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 29403010) Youthful appearance (self-reported) ( 32339537)	L1-L4 bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		6 interacting genes: CCDC187 DISC1 PDCD10 PELI2 PRR35 SHANK3	80 interacting genes: ABHD11 ACTMAP ACY1 APPL2 ARMC5 ASB15 BEGAIN BIRC7 BPIFA1 CARD10 CCDC136 CFAP68 CNOT2 CRX CYSRT1 EXOC8 FAM168B FHL3 FRYL GIGYF1 GRAP2 HOMER3 HOOK2 HPCA HSPB2 HSPB2-C11orf52 INSC INTS11 JUP KLHL26 KRT31 KRT34 KRT35 KRTAP10-7 KRTAP12-1 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 LASP1 LONRF1 LZTS2 MAGED1 MCCD1 MKRN3 MSS51 MTUS2 N4BP3 NBPF19 NOTCH2NLA OIP5 OXER1 PFDN5 PLAGL2 PPIL1 PPP1R13B PRR20A PRR20B PRR20C PRR20D PRR20E PSTPIP1 RBPMS RNF144B RUSC1 SMUG1 SPAG8 TBX19 TLE5 TRIM27 TRIM54 TRIM73 TTC19 TTLL12 UBASH3B UBXN11 USP54 ZMYND12 ZNF655
Entrez ID		285527	146325
HPRD ID		18995	10046
Ensembl ID		ENSG00000075539	ENSG00000161992
Uniprot IDs		A0A2C9F2R7 B3KXG5 O94915 Q6ZR29	P0CG20
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Presynaptic Actin Cytoskeleton Actin Filament Bundle Assembly Actin Filament Bundle Organization Cytoskeleton Organization Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Dendritic Spine Development Organelle Organization Actin Filament Bundle Presynaptic Cytoskeleton Organization Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Establishment Of Golgi Localization Golgi Reassembly Positive Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Protein Phosphorylation Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Neurogenesis Regulation Of Postsynapse Organization Pyramidal Neuron Migration To Cerebral Cortex Cerebral Cortex Radial Glia-guided Migration Central Region Of Growth Cone Regulation Of Toll Signaling Pathway Guanylate Kinase-associated Protein Clustering Vocal Learning Negative Regulation Of Cell Volume Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Observational Learning Striatal Medium Spiny Neuron Differentiation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphorylation Postsynaptic Density Postsynaptic Specialization Assembly Actin Filament Organization GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Nervous System Development Endothelium Development Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis	Intermediate Filament Keratin Filament
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