FRYL and CCDC187

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FRYL	CCDC187
Description		FRY like transcription coactivator	coiled-coil domain containing 187
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Cortex Site Of Polarized Growth	Centrosome
	Molecular Function	Protein Binding	Microtubule Binding
	Biological Process	Cell Morphogenesis Neuron Projection Development	Microtubule Anchoring
Pathways			RHOC GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Height ( 31562340) Hemoglobin ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 29403010) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		6 interacting genes: CCDC187 DISC1 PDCD10 PELI2 PRR35 SHANK3	72 interacting genes: ACTN2 ANKRD28 AP2B1 ASB15 BICD2 CARD10 CBY2 CCDC102B CCDC136 CCNDBP1 CDR2 CDR2L CEP63 CEP70 COG6 CRACR2B CSNK2B CYSRT1 DDX17 DEUP1 EFS FRYL FSD2 FXR1 GOLGA2 GOLGA6A GOLGA6L9 GRIPAP1 HMBOX1 HNRNPK HOMER3 HOMEZ HOOK2 HSF2BP IKZF3 INSC KHDRBS3 KIFC3 KRT15 KRT27 KRT31 KRT32 KRTAP6-1 LZTS1 LZTS2 MAGEA6 MCC MDFI MID2 MKRN3 MSS51 MTUS2 NAB2 NCKIPSD PICK1 PLEKHG4 PNMA1 PNMA3 PRKAR1B RINT1 SORBS3 SSX2IP TFIP11 TRAF1 TRAF2 TRIM27 TRIM54 TRIP6 USHBP1 VIM VPS52 ZRANB1
Entrez ID		285527	399693
HPRD ID		18995	14668
Ensembl ID		ENSG00000075539	ENSG00000260220
Uniprot IDs		A0A2C9F2R7 B3KXG5 O94915 Q6ZR29	A0A096LP49 A0A1W2PQX5
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Presynaptic Actin Cytoskeleton Actin Filament Bundle Assembly Actin Filament Bundle Organization Cytoskeleton Organization Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Dendritic Spine Development Organelle Organization Actin Filament Bundle Presynaptic Cytoskeleton Organization Presynaptic Actin Cytoskeleton Organization Actin Filament Network Formation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Establishment Of Golgi Localization Golgi Reassembly Positive Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Protein Phosphorylation Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Neurogenesis Regulation Of Postsynapse Organization Pyramidal Neuron Migration To Cerebral Cortex Cerebral Cortex Radial Glia-guided Migration Central Region Of Growth Cone Regulation Of Toll Signaling Pathway Guanylate Kinase-associated Protein Clustering Vocal Learning Negative Regulation Of Cell Volume Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Observational Learning Striatal Medium Spiny Neuron Differentiation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Phosphorylation Postsynaptic Density Postsynaptic Specialization Assembly Actin Filament Organization GABAergic Neuron Differentiation Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Nervous System Development Endothelium Development Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis	Protein Domain Specific Binding Protein Binding Identical Protein Binding Cytoskeleton Intermediate Filament Intermediate Filament Organization Organelle Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Cytoplasm Structural Constituent Of Skin Epidermis De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation De Novo Centriole Assembly Cytosol Microtubule Organizing Center Organization Microtubule
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