TPRG1 and APOC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TPRG1	APOC1
Description		tumor protein p63 regulated 1	apolipoprotein C1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Extracellular Region Endoplasmic Reticulum Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron
	Molecular Function	Protein Binding	Phospholipase Inhibitor Activity Fatty Acid Binding Protein Binding Phosphatidylcholine Binding Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity
	Biological Process		Lipid Metabolic Process Triglyceride Metabolic Process Lipid Transport Cholesterol Metabolic Process Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Plasma Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Very-low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Triglyceride Homeostasis
Pathways			VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Allergic rhinitis ( 30013184) Asthma ( 31959851) Axial length ( 24144296) Cutaneous squamous cell carcinoma ( 32041948) Femur bone mineral density x serum urate levels interaction ( 34046847) Hair color ( 26926045) Squamous cell carcinoma ( 26829030)	Alzheimer's disease ( 17998437 22832961 24755620 30636644) Alzheimer's disease (age of onset) ( 22005931) Alzheimer's disease biomarkers ( 23419831) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Apolipoprotein Levels ( 23031429) Aspartate aminotransferase levels ( 33547301) Body fat percentage ( 26833246) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) C-reactive protein ( 19567438) C-reactive protein levels ( 21300955 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Carotid intima media thickness ( 21909108) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Cerebral amyloid deposition (PET imaging) ( 26252872 30361487) Cerebral amyloid deposition positivity (PET imaging) ( 26252872) Cerebral cortex AV-45 amyloid PET measurement ( 31755389) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 28641921 29274321 30319691) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid p-Tau181p:AB1-42 ratio ( 30319691) Cerebrospinal fluid t-tau levels ( 28641921 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921 30319691) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cholesterol, total ( 20686565) Cingulate cortical amyloid beta load ( 26421299) Cognitive impairment test score ( 30319691) Coronary artery disease ( 26343387 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) HDL cholesterol ( 20686565) HDL cholesterol levels ( 28334899 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 30718733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip index ( 34021172) Hippocampal atrophy rate ( 31760383) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Ideal cardiovascular health (clinical) ( 27179730) Immature fraction of reticulocytes ( 32888494) Lamb consumption ( 32066663) LDL cholesterol ( 18193043 18193044 18262040 18802019 19060906 20686565 20864672 26160806) LDL cholesterol levels ( 28334899 28371326) LDL cholesterol to HDL cholesterol ratio ( 28046027) Lipid metabolism phenotypes ( 19936222 22286219) Lipid traits ( 24023261) Lipoprotein (a) levels ( 33730874) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857 22003152 23118302) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Longevity ( 21740922) Low density lipoprotein cholesterol levels ( 28548082) Mean corpuscular hemoglobin concentration ( 32888494) Meat-related diet ( 32066663) Mental health study participation (completed survey) ( 31263887) Metabolic syndrome ( 31589552) Metabolically unhealthy in normal weight ( 33500527) Myocardial infarction ( 26343387) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Quantitative traits ( 19197348) Red cell distribution width ( 28957414) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Resting heart rate ( 27798624) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 28548082 30275531) Triglyceride levels ( 28334899 31217584 32203549 33339817) Triglycerides ( 20686565 23726366) Type 2 diabetes ( 28869590) Verbal declarative memory ( 25648963) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: APOC1 APOC2 APOC4 AQP6 CGRRF1 CIDEB EBAG9 FCER1G HSD17B11 HSD17B13 REEP4 RETREG3 RHBDD2 SCN3B SLC10A6 SLC35H1 SLC71A2 TMEM120A TMX2	30 interacting genes: ACACA ACSF2 APOA1 APOA2 ATP5MJ BCL2L2 CIDEB DBX1 DHRSX FOXD4L3 GSDMA H4C7 HIGD1C LETMD1 MAIP1 MICOS13 MPC2 MTCH2 MTERF3 NFU1 NSG2 RADIL RSAD2 RTP5 SIRPB1 SPG21 SYT16 TEX44 TPRG1 VKORC1
Entrez ID		285386	341
HPRD ID		13451	00131
Ensembl ID		ENSG00000188001	ENSG00000130208
Uniprot IDs		Q6ZUI0	K7EPF9 P02654
PDB IDs			1ALE 1ALF 1IOJ 1OPP 6DVU 6DXR 6DZ6 6NF3
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Steroid Dehydrogenase Activity Acylglycerol Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Triglyceride Homeostasis Regulation Of Triglyceride Metabolic Process Endoplasmic Reticulum Lipid Transport Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Organic Hydroxy Compound Transport Very-low-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Lipid Droplet Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Regulation Of Lipid Metabolic Process Plasma Lipoprotein Particle Clearance Organophosphate Ester Transport Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Metabolic Process Lipid Storage Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Lipid Homeostasis Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Negative Regulation Of Phosphatidylcholine Catabolic Process Nitrate Transmembrane Transporter Activity Transmembrane Transport IgE Receptor Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Regulation Of Lipid Biosynthetic Process Regulation Of Fatty Acid Biosynthetic Process Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Regulation Of Lipid Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling PH-gated Chloride Channel Activity Nitrate Transmembrane Transport	Mitochondrion Mitochondrion Organization Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Apolipoprotein Receptor Binding Organophosphate Biosynthetic Process Cellular Response To Lipoprotein Particle Stimulus Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Phagocytosis Protein Oxidation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Mitochondrial Outer Membrane Regulation Of Intestinal Cholesterol Absorption High-density Lipoprotein Particle Clearance Spherical High-density Lipoprotein Particle Mitochondrial Inner Membrane High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption Organophosphate Metabolic Process High-density Lipoprotein Particle Binding Lipid Homeostasis Apoptotic Mitochondrial Changes Calcium Import Into The Mitochondrion Chylomicron Phospholipid Efflux Regulation Of Intestinal Absorption Protein Insertion Into Membrane Establishment Of Protein Localization To Mitochondrion Positive Regulation Of Phagocytosis Reverse Cholesterol Transport Phosphate-containing Compound Metabolic Process Cellular Response To Prostaglandin E Stimulus Acyl-CoA Metabolic Process Protein Binding Mitochondrial Calcium Ion Transmembrane Transport Establishment Of Protein Localization To Membrane Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Lipid Droplet Purine-containing Compound Biosynthetic Process Chemical Homeostasis Small Molecule Metabolic Process Phosphatidylcholine Biosynthetic Process Mitochondrial Calcium Ion Homeostasis High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Cellular Response To Prostaglandin Stimulus
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