GSDMA and APOC4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GSDMA	APOC4
Description		gasdermin A	apolipoprotein C4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding	Lipid Transporter Activity Protein Binding
	Biological Process	Programmed Cell Death Defense Response To Bacterium Transmembrane Transport Pyroptotic Inflammatory Response	Lipid Metabolic Process Lipid Transport Lipid Storage Triglyceride Homeostasis
Pathways			VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Asthma ( 20860503 31959851 31619474 29785011) Asthma (childhood onset) ( 24241537) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 28067908) Hematological parameters ( 19820697) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Refractive error ( 32231278) Systemic sclerosis ( 28314753) Ulcerative colitis ( 28067908) White blood cell count ( 22037903 21738480 20139978)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 20864672 19060906 18802019 18193044 18193043) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		3 interacting genes: APOC1 APOC2 APOC4	24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1
Entrez ID		284110	346
HPRD ID		17081	02848
Ensembl ID		ENSG00000167914	ENSG00000267467
Uniprot IDs		Q96QA5	P55056
PDB IDs
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Acylglycerol Homeostasis Triglyceride Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Chylomicron Phospholipid Efflux Lipid Homeostasis Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Clearance Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Metabolic Process Lipid Transport Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Regulation Of Triglyceride Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Negative Regulation Of Endocytosis Sterol Transport Phospholipid Transport Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Receptor-mediated Endocytosis Regulation Of Ketone Metabolic Process Regulation Of Lipid Transport Organophosphate Ester Transport Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Chemical Homeostasis Organic Hydroxy Compound Transport Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Regulation Of Lipid Biosynthetic Process Lipid Metabolic Process Chylomicron Remodeling Very-low-density Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Phosphatidylcholine-sterol O-acyltransferase Activator Activity	Virion Assembly Membrane Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Inner Mitochondrial Membrane Organization MICOS Complex Mitochondrial Crista Junction SAM Complex MIB Complex Host-mediated Perturbation Of Viral Genome Replication Mitochondrial Membrane Cristae Formation Host-mediated Perturbation Of Viral Process Mitochondrial Outer Membrane Negative Regulation Of Platelet Activation Positive Regulation Of ERAD Pathway Mitochondrial Calcium Ion Homeostasis Host-mediated Perturbation Of Symbiont Process Mitochondrial Membrane Organization Modulation Of Process Of Another Organism Extrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Host-mediated Activation Of Viral Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Coagulation Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Palmitoleoyltransferase Activity Protein Palmitoleylation Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response 4 Iron, 4 Sulfur Cluster Binding Organelle Organization Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Protein Binding Regulation Of Platelet Activation
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