GSDMA

Description		gasdermin A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding
	Biological Process	Programmed Cell Death Defense Response To Bacterium Transmembrane Transport Pyroptotic Inflammatory Response
Pathways
Drugs
Diseases
GWAS		Asthma ( 20860503 31959851 31619474 29785011) Asthma (childhood onset) ( 24241537) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 28067908) Hematological parameters ( 19820697) Inflammatory bowel disease ( 23128233 28067908) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lymphocyte percentage of white cells ( 32888494) Refractive error ( 32231278) Systemic sclerosis ( 28314753) Ulcerative colitis ( 28067908) White blood cell count ( 22037903 21738480 20139978)
Novel Interacting Genes		1 novel interacting genes: CISD3
Interacting Genes		3 interacting genes: APOC1 APOC2 APOC4
Entrez ID		284110
HPRD ID		17081
Ensembl ID		ENSG00000167914
Uniprot IDs		Q96QA5
PDB IDs
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Acylglycerol Homeostasis Triglyceride Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Chylomicron Phospholipid Efflux Lipid Homeostasis Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Cholesterol Transport Plasma Lipoprotein Particle Clearance Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Metabolic Process Lipid Transport Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Regulation Of Triglyceride Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Negative Regulation Of Endocytosis Sterol Transport Phospholipid Transport Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Receptor-mediated Endocytosis Regulation Of Ketone Metabolic Process Regulation Of Lipid Transport Organophosphate Ester Transport Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Chemical Homeostasis Organic Hydroxy Compound Transport Regulation Of Phosphatidylcholine Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Lipoprotein Lipase Activator Activity Regulation Of Lipid Biosynthetic Process Lipid Metabolic Process Chylomicron Remodeling Very-low-density Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Phosphatidylcholine-sterol O-acyltransferase Activator Activity
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