DRC12 and GNMT

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DRC12	GNMT
Name		dynein regulatory complex subunit 12 homolog	glycine N-methyltransferase
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Motile Cilium Cell Projection	Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Folic Acid Binding Methyltransferase Activity Glycine Binding Transferase Activity Glycine N-methyltransferase Activity Identical Protein Binding S-adenosyl-L-methionine Binding
	Biological Process	None	Glycogen Metabolic Process Regulation Of Gluconeogenesis Methionine Metabolic Process One-carbon Metabolic Process Methylation S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Protein Homotetramerization Sarcosine Metabolic Process
Pathways		None	Metabolism of ingested SeMet, Sec, MeSec into H2Se Glyoxylate metabolism and glycine degradation Developmental Lineage of Pancreatic Acinar Cells
Drugs		None	Ademetionine Glycine S-adenosyl-L-homocysteine
Diseases		None	Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		No GWAS studies recorded	Apolipoprotein B levels ( 32203549 ) Blood protein levels ( 30072576 ) LDL cholesterol levels ( 32203549 ) Plasma homocysteine levels (post-methionine load test) ( 24651765 )
Novel Interactors		None recorded	1 novel interactors: STT3B
Interacting Genes		18 interacting genes: AIMP2 BFSP2 C19orf25 CDR2 CDR2L DDIT3 DTNBP1 FAM124B GNMT GORASP2 GUCD1 NECAB2 NUP62 PIN1 POLR2J PSMA1 SPG21 STX5	31 interacting genes: ADAMTSL4 ARR3 ARRB1 COX7B CTNS DRC12 FRG1 GABRQ GAGE2A HDAC7 HPRT1 KRTAP10-3 KRTAP4-2 NIF3L1 NOTCH2NLA NTAQ1 NUDT18 OTOS PLEKHF2 POT1 PRKACA RPSA SDCBP SNRNP200 SRD5A2 TERF1 TERF2 TERF2IP TINF2 TRIM35 ZNF337
Entrez ID		283152	27232
HPRD ID		18762	05970
Ensembl ID		ENSG00000248712	ENSG00000124713
Uniprot IDs		Q494R4	A0A0S2Z5F2 Q14749 V9HW60
PDB IDs		Not available	1R74 2AZT
GO Terms Enriched among Interactors		None	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding G-rich Strand Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Chromosome Organization Telomeric D-loop Disassembly Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of DNA Recombination At Telomere Telomere Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Chromosome, Telomeric Region Regulation Of DNA Biosynthetic Process Telomere Assembly DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomerase Activity Protection From Non-homologous End Joining At Telomere Regulation Of Chromosome Organization Double-stranded Telomeric DNA Binding Positive Regulation Of DNA Metabolic Process G Protein-coupled Receptor Internalization Telomere Maintenance In Response To DNA Damage Positive Regulation Of Organelle Organization Grooming Behavior Chromosome Organization Nuclear Body Positive Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-2 Production Protein Localization To Chromosome Striated Muscle Dense Body Guanine Phosphoribosyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Component Organization Interleukin-5 Receptor Complex