CMKLR2 and TPST1

Number of citations of the paper that reports this interaction (PubMedID 17558413)
0

Data Source:
HPRD (in vitro)

		CMKLR2	TPST1
Description		chemerin chemokine-like receptor 2	tyrosylprotein sulfotransferase 1
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GO Annotations	Cellular Component	Nucleoplasm Plasma Membrane Membrane Neuron Projection	Golgi Membrane Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Binding Adipokinetic Hormone Receptor Activity Adipokinetic Hormone Binding	Protein-tyrosine Sulfotransferase Activity Transferase Activity Protein Homodimerization Activity
	Biological Process	Cell Communication Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Signaling Glucose Homeostasis	Post-translational Protein Modification 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process
Pathways			Cytosolic sulfonation of small molecules Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Defective F8 sulfation at Y1699
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Gout ( 22179738)
Interacting Genes		3 interacting genes: GNAI1 TPST1 TPST2	9 interacting genes: CCR1 CCR8 CMKLR1 CMKLR2 GOLPH3 GOLPH3L GP1BA SELPLG TMEM132D
Entrez ID		2825	8460
HPRD ID		02585	07216
Ensembl ID		ENSG00000183671	ENSG00000169902
Uniprot IDs		P46091	O60507
PDB IDs		8JJP 8XGM 9L3Y	5WRI 5WRJ
Enriched GO Terms of Interacting Partners?		Protein-tyrosine Sulfotransferase Activity 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Peptidyl-tyrosine Sulfation Trans-Golgi Network D2 Dopamine Receptor Binding Adenylate Cyclase Inhibitor Activity Positive Regulation Of Relaxation Of Smooth Muscle Adenylate Cyclase Regulator Activity G Protein-coupled Serotonin Receptor Binding Golgi Apparatus Sulfur Compound Metabolic Process Protein Sulfation Purine Ribonucleotide Metabolic Process Prevention Of Polyspermy Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Positive Regulation Of Protein Localization To Cell Cortex Purine Nucleotide Metabolic Process Regulation Of Protein Localization To Cell Cortex Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Nucleotide Metabolic Process Regulation Of Fertilization Purine-containing Compound Metabolic Process Cellular Response To Forskolin Guanyl Nucleotide Binding Response To Forskolin Regulation Of Relaxation Of Muscle Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sulfation Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Plasma Membrane Fusion Golgi Membrane Response To Prostaglandin E Protein Homodimerization Activity Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Cholesterol Metabolic Process Organic Acid Metabolic Process Positive Regulation Of Steroid Biosynthetic Process T Cell Migration Heterotrimeric G-protein Complex Carbohydrate Derivative Metabolic Process Negative Regulation Of Insulin Secretion Regulation Of Mitotic Spindle Organization Positive Regulation Of Steroid Metabolic Process Negative Regulation Of Peptide Secretion	Chemokine Receptor Activity Adipokinetic Hormone Binding Adipokinetic Hormone Receptor Activity Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Chemokine-mediated Signaling Pathway Golgi Cisterna G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration C-C Chemokine Binding C-C Chemokine Receptor Activity Leukocyte Tethering Or Rolling Leukocyte Adhesion To Vascular Endothelial Cell Phosphatidylinositol-4-phosphate Binding Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Leukocyte Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Chemotaxis Golgi Cisterna Membrane External Side Of Plasma Membrane Locomotion Cell Migration Positive Regulation Of Mononuclear Cell Migration Cytokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Leukocyte Chemotaxis Chemokine (C-C Motif) Ligand 7 Binding Cellular Response To Cytokine Stimulus Leukocyte Adhesive Activation Asymmetric Golgi Ribbon Formation Post-Golgi Vesicle-mediated Transport Cell Motility Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Organization Plasma Membrane Protein Retention In Golgi Apparatus Vesicle-mediated Transport To The Plasma Membrane Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Response To Peptide Positive Regulation Of Chemotaxis Response To Cytokine
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