GP2 and ANXA4

Number of citations: 0 (PubMedID 12324456)
Data Source: HPRD (in vitro)

		GP2	ANXA4
Name		glycoprotein 2	annexin A4
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cytoplasmic Vesicle Zymogen Granule Membrane Membrane Raft Extracellular Exosome Side Of Membrane	Nucleus Cytoplasm Plasma Membrane Cell Surface Vesicle Membrane Membrane Extracellular Matrix Cytoplasmic Vesicle Nuclear Membrane Zymogen Granule Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Antigen Binding Protein Binding	Phosphatidylserine Binding Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding Transcription Regulator Inhibitor Activity
	Biological Process	Immune System Process Antigen Transcytosis By M Cells In Mucosal-associated Lymphoid Tissue Innate Immune Response Neutrophil Migration	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Notch Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of Interleukin-8 Production Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Developmental Lineage of Pancreatic Acinar Cells	None
Drugs		None	Fluocinolone acetonide Copper
GWAS		Adult body size ( 32376654 ) Body mass index ( 22344219 24861553 28892062 ) Body size at age 10 ( 32376654 ) Chronic kidney disease ( 20383146 ) Diastolic blood pressure x smoking status (ever vs never) interaction (1df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945 ) Type 1 diabetes ( 34012112 ) Type 2 diabetes ( 30718926 32499647 )	Atrial fibrillation ( 28416818 30061737 ) Palmitoleic acid (16:1n-7) levels ( 23362303 )
Interacting Genes		6 interacting genes: AMY2A ANXA4 GLP1R JAGN1 SOX30 TSSK3	8 interacting genes: GP2 NMT2 PADI4 POT1 RHOU SMPD1 TINF2 UCHL5
Entrez ID		2813	307
HPRD ID		04279	00112
Ensembl ID		ENSG00000169347	ENSG00000196975
Uniprot IDs		B7Z1G2 P55259	P09525 Q6P452
PDB IDs		7P6R 7P6S 7P6T	2ZOC
GO Terms Enriched among Interactors		Alpha-amylase Activity Hormone Secretion Hormone Transport Glucagon-like Peptide 1 Receptor Activity Spermatid Development Proacrosomal Vesicle Fusion Glucagon Receptor Activity Polysaccharide Digestion Response To Psychosocial Stress Signal Release Germ Cell Development Granulocyte Colony-stimulating Factor Signaling Pathway	Telomere Assembly Positive Regulation Of Telomere Maintenance Shelterin Complex Nuclear Telomere Cap Complex Telomere Maintenance Positive Regulation Of Chromosome Organization Telomere Capping Regulation Of Telomere Maintenance Regulation Of DNA Strand Elongation Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Component Organization Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Antigen Transcytosis By M Cells In Mucosal-associated Lymphoid Tissue Phosphatidylcholine Phospholipase C Activity Acid Sphingomyelin Phosphodiesterase Activity Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Glycylpeptide N-tetradecanoyltransferase Activity N-terminal Peptidyl-glycine N-myristoylation Peptidyl-lysine N6-myristoyltransferase Activity Histone H3R26 Arginine Deiminase Activity Histone Arginine Deiminase Activity Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Regulation Of DNA Metabolic Process Termination Of Signal Transduction 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of Organelle Organization Negative Regulation Of DNA Metabolic Process N-terminal Protein Myristoylation Telomeric D-loop Binding Protein-arginine Deiminase Activity Single-stranded Telomeric DNA Binding Regulation Of Cellular Component Organization