AMT and IMPDH2

		AMT	IMPDH2
Description		aminomethyltransferase	inosine monophosphate dehydrogenase 2
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Extracellular Region Nucleus Cytoplasm Peroxisomal Membrane Cytosol Membrane Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Aminomethyltransferase Activity Protein Binding Transaminase Activity Transferase Activity	Nucleotide Binding DNA Binding RNA Binding Catalytic Activity IMP Dehydrogenase Activity Protein Binding Oxidoreductase Activity Metal Ion Binding
	Biological Process	Glycine Catabolic Process Glycine Decarboxylation Via Glycine Cleavage System	Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process GTP Biosynthetic Process Circadian Rhythm Lymphocyte Proliferation Cellular Response To Interleukin-4 'de Novo' XMP Biosynthetic Process
Pathways		Glycine degradation	Neutrophil degranulation Purine ribonucleoside monophosphate biosynthesis Potential therapeutics for SARS Azathioprine ADME
Drugs		Tetrahydrofolic acid NADH 5-methyltetrahydrofolic acid	NADH Mycophenolate mofetil Ribavirin Mycophenolic acid Mercaptopurine Selenazole-4-carboxyamide-adenine dinucleotide 6-Chloropurine Riboside, 5'-Monophosphate Inosinic Acid VX-148
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: PDLIM4 VAC14	17 interacting genes: AGR2 AKT1 APIP CEBPA CLK1 CPLANE2 FXR1 FXR2 IL1F10 OGT PIAS4 POU6F2 STAT3 SUMO2 SUMO4 TRAF2 UBQLN4
Entrez ID		275	3615
HPRD ID		01997	00895
Ensembl ID		ENSG00000145020	ENSG00000178035
Uniprot IDs		P48728	A0A7I2YQK5 E7ETK5 H0Y4R1 P12268
PDB IDs		1WSR 1WSV	1B3O 1NF7 1NFB 6I0M 6I0O 6U8E 6U8N 6U8R 6U8S 6U9O 6UA2 6UA4 6UA5 6UAJ 6UC2 6UDO 6UDP 6UDQ 8FOZ 8FUZ 8G8F 8G9B 9DMU
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Translation Identical Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process TOR Signaling Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Homodimerization Activity Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of Gene Expression Inflammatory Response Negative Regulation Of Double-strand Break Repair Positive Regulation Of MRNA Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex Negative Regulation Of Catabolic Process Negative Regulation Of DNA Repair Glutamatergic Synapse Negative Regulation Of Translational Initiation Cytokine-mediated Signaling Pathway Regulation Of Translation Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA Recombination Positive Regulation Of Long-term Neuronal Synaptic Plasticity Protein Sumoylation Defense Response Positive Regulation Of MRNA Metabolic Process
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