SLC12A2 and COMMD1

Number of citations of the paper that reports this interaction (PMID 23515529)
1

Data Source:
BioGRID (two hybrid, pull down)

		SLC12A2	COMMD1
Gene Name		solute carrier family 12 (sodium/potassium/chloride transporter), member 2	copper metabolism (Murr1) domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Vesicle Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Early Endosome Cul2-RING Ubiquitin Ligase Complex Recycling Endosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Transmembrane Transporter Activity	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Transport Ion Transport Potassium Ion Transport Sodium Ion Transport Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway Ammonium Transport Transepithelial Chloride Transport Multicellular Organism Growth Positive Regulation Of Cell Volume Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Transmembrane Transport Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Transepithelial Ammonium Transport Ammonium Transmembrane Transport Chloride Transmembrane Transport	Golgi To Plasma Membrane Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Plasma Membrane To Endosome Transport Copper Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Localization To Cell Surface
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs		Potassium Chloride Bumetanide Quinethazone
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Ileal carcinoids ( 21139019)
Protein-Protein Interactions		3 interactors: COMMD1 OXSR1 STK39	27 interactors: BAHCC1 BARD1 BRCA1 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 KAT2A LIG4 NFKBIA RELA SLC12A2 SOCS1 SPP1 TCEB1 XIAP
Entrez ID		6558	150684
HPRD ID		06775	06253
Ensembl ID		ENSG00000064651
Uniprot IDs		B7ZM24 P55011 Q53ZR1	Q8N668
PDB IDs			2H2M
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Negative Regulation Of Ion Transport Regulation Of Rubidium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Hypotonic Response Hypotonic Response Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Osmotic Stress Negative Regulation Of Transport Regulation Of Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Peptidyl-threonine Phosphorylation Regulation Of Ion Transport Regulation Of Potassium Ion Transport Response To Osmotic Stress Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Signal Transduction By Phosphorylation Negative Regulation Of Sodium Ion Transmembrane Transport Plasma Membrane To Endosome Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transport Regulation Of Protein Localization To Cell Surface Copper Ion Homeostasis Positive Regulation Of Potassium Ion Transport Golgi To Plasma Membrane Transport Regulation Of Sodium Ion Transmembrane Transport Peptidyl-amino Acid Modification Response To Abiotic Stimulus Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sodium Ion Transport Protein Phosphorylation Post-Golgi Vesicle-mediated Transport Cellular Response To Stress Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Phosphorylation Intracellular Signal Transduction Transition Metal Ion Homeostasis	Protein Ubiquitination Protein Modification By Small Protein Conjugation Viral Process Intrinsic Apoptotic Signaling Pathway Cell Cycle Arrest Ubiquitin-dependent Protein Catabolic Process Response To Stress Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stress Apoptotic Signaling Pathway Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Cell Cycle Cellular Response To Stimulus Apoptotic Process Cell Cycle Negative Regulation Of Cell Cycle Programmed Cell Death Cell Death Death Response To Abiotic Stimulus Regulation Of Cell Proliferation G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Process Intracellular Signal Transduction Cell Cycle Process Response To Stimulus Proteolysis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Modification Process Regulation Of Metabolic Process Protein Monoubiquitination Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Phase Transition Protein K6-linked Ubiquitination Mitotic Cell Cycle Process Negative Regulation Of NF-kappaB Transcription Factor Activity Protein Metabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Metabolic Process
Tagcloud ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 strengths tnik trait unanticipated visualizing	beneficial cart comparative considering edged eradication hiv ikappab infected innate jak latency latent lymphoid murr1 parental poses proteasomal reactivation reinforcing respective restriction retroviral sets stabilized suppressing sword tnfalpha toll
Tagcloud (Difference) ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 strengths tnik trait unanticipated visualizing	beneficial cart comparative considering edged eradication hiv ikappab infected innate jak latency latent lymphoid murr1 parental poses proteasomal reactivation reinforcing respective restriction retroviral sets stabilized suppressing sword tnfalpha toll
Tagcloud (Intersection) ?