SLC12A2 and OXSR1

Number of citations of the paper that reports this interaction (PMID 16669787)
49

Data Source:
HPRD (in vitro)

		SLC12A2	OXSR1
Gene Name		solute carrier family 12 (sodium/potassium/chloride transporter), member 2	oxidative stress responsive 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Vesicle Extracellular Vesicular Exosome	Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Transmembrane Transporter Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Transport Ion Transport Potassium Ion Transport Sodium Ion Transport Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway Ammonium Transport Transepithelial Chloride Transport Multicellular Organism Growth Positive Regulation Of Cell Volume Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Transmembrane Transport Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Transepithelial Ammonium Transport Ammonium Transmembrane Transport Chloride Transmembrane Transport	Protein Phosphorylation Response To Oxidative Stress Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Intracellular Signal Transduction Cellular Hypotonic Response Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Cation-coupled Chloride cotransporters SLC-mediated transmembrane transport
Drugs		Potassium Chloride Bumetanide Quinethazone
Diseases
GWAS		Brain imaging in schizophrenia (interaction) ( 19023125) Ileal carcinoids ( 21139019)
Protein-Protein Interactions		3 interactors: COMMD1 OXSR1 STK39	10 interactors: APP BMPR1B PAK1 RELL1 RELL2 SLC12A1 SLC12A2 SLC12A6 SMURF1 TGFBR1
Entrez ID		6558	9943
HPRD ID		06775	06809
Ensembl ID		ENSG00000064651	ENSG00000172939
Uniprot IDs		B7ZM24 P55011 Q53ZR1	O95747
PDB IDs			2V3S 2VWI 3DAK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Rubidium Ion Transport Negative Regulation Of Rubidium Ion Transmembrane Transporter Activity Negative Regulation Of Ion Transport Regulation Of Rubidium Ion Transport Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Hypotonic Response Hypotonic Response Negative Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Cellular Response To Osmotic Stress Negative Regulation Of Transport Regulation Of Ion Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Transporter Activity Peptidyl-threonine Phosphorylation Regulation Of Ion Transport Regulation Of Potassium Ion Transport Response To Osmotic Stress Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Signal Transduction By Phosphorylation Negative Regulation Of Sodium Ion Transmembrane Transport Plasma Membrane To Endosome Transport Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Sodium Ion Transport Regulation Of Protein Localization To Cell Surface Copper Ion Homeostasis Positive Regulation Of Potassium Ion Transport Golgi To Plasma Membrane Transport Regulation Of Sodium Ion Transmembrane Transport Peptidyl-amino Acid Modification Response To Abiotic Stimulus Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sodium Ion Transport Protein Phosphorylation Post-Golgi Vesicle-mediated Transport Cellular Response To Stress Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Phosphorylation Intracellular Signal Transduction Transition Metal Ion Homeostasis	Response To Osmotic Stress Chloride Transmembrane Transport Chloride Transport Anatomical Structure Development Hyperosmotic Response Potassium Ion Transport Developmental Process Anatomical Structure Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Inorganic Anion Transport Signal Transduction By Phosphorylation Developmental Growth System Development Peptidyl-threonine Phosphorylation Neuromuscular Junction Development Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Guidance BMP Signaling Pathway Anion Transmembrane Transport Positive Regulation Of Cell Volume Rubidium Ion Transport Cellular Hypotonic Salinity Response Cell Morphogenesis Response To Abiotic Stimulus Regulation Of Cartilage Development Neuron Differentiation Response To Stress Epithelial Cell Migration Epithelium Migration Growth Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Synaptic Growth At Neuromuscular Junction Negative Regulation Of Chondrocyte Proliferation Ovarian Cumulus Expansion Locomotion Axonogenesis Protein Phosphorylation Axon Development Transepithelial Ammonium Transport Collateral Sprouting In Absence Of Injury Cell Morphogenesis Involved In Neuron Differentiation Dendrite Development Wound Healing
Tagcloud ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 strengths tnik trait unanticipated visualizing
Tagcloud (Difference) ?		arhgap18 circuitry connectivity ctxn3 deeper dlpfc epistatic fgf17 forebrain glypican gpc1 gsea gwas leverages networks neuroimaging perturbed postmortem qt quantifying reorganization robo1 robo2 rsrc1 strengths tnik trait unanticipated visualizing
Tagcloud (Intersection) ?