TMEM97 and RNF170

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM97	RNF170
Description		transmembrane protein 97	ring finger protein 170
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Lysosome Endoplasmic Reticulum Rough Endoplasmic Reticulum Plasma Membrane Membrane Rough Endoplasmic Reticulum Membrane Nuclear Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Oxysterol Binding Cholesterol Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Cell Growth Regulation Of Intracellular Lipid Transport Regulation Of Intracellular Cholesterol Transport Cholesterol Homeostasis Positive Regulation Of Wound Healing Positive Regulation Of Lipoprotein Transport	Protein Polyubiquitination Adult Walking Behavior Response To Temperature Stimulus Gene Expression Proteasomal Protein Catabolic Process Response To Activity Protein Ubiquitination Protein Catabolic Process Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Protein K48-linked Ubiquitination Walking Behavior
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Osteoprotegerin levels ( 25080503)
Interacting Genes		66 interacting genes: APP AQP12B AQP2 AQP6 ARL13B ASZ1 ATP6AP2 BCL2L13 BIK CD53 CD74 CD79A CGRRF1 CLDN7 CLSTN3 CPLX4 EBP ERGIC3 FAM209A FFAR2 FKBP7 FRMD3 FXYD3 GJA8 GJB3 GJB5 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LEUTX LHFPL5 LIME1 LRRC59 MFF MRM1 MTIF3 MUC1 NDUFAF1 NDUFAF2 NEMP1 PDCD1LG2 PDZK1IP1 PLP1 PSCA REEP1 RHCG RNF170 SAR1A SGPL1 SLC10A1 SLC14A1 SLC14A2 SLC18A1 SLC35H1 SPINT1 SSMEM1 TMEM106C TMEM14B TMEM45B TMEM52B TMEM79 TMX2 VSIR	15 interacting genes: DNAJC30 FXYD6-FXYD2 HACD1 PLPP6 PSMA6 SGTA SGTB SNAP47 STARD3 TMEM109 TMEM97 UBE2D2 UBE2L3 UBE2U UPK2
Entrez ID		27346	81790
HPRD ID		14343	13165
Ensembl ID		ENSG00000109084	ENSG00000120925
Uniprot IDs		Q5BJF2	Q96K19
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Water Transport One-carbon Compound Transport Fluid Transport Protein Binding Water Channel Activity Endoplasmic Reticulum Membrane Connexin Complex Endoplasmic Reticulum Gap Junction Channel Activity Plasma Membrane B Cell Receptor Complex Water Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Mitochondrial Membrane Gap Junction Urea Transmembrane Transporter Activity Transmembrane Transport	TRC Complex Ubiquitin Conjugating Enzyme Activity Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-like Protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Purine Ribonucleoside Triphosphate Binding Establishment Of Protein Localization To Membrane Protein Targeting Cholesterol Binding Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process
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