TMEM97 and ADCYAP1R1

		TMEM97	ADCYAP1R1
Description		transmembrane protein 97	ADCYAP receptor type I
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Lysosome Endoplasmic Reticulum Rough Endoplasmic Reticulum Plasma Membrane Membrane Rough Endoplasmic Reticulum Membrane Nuclear Membrane	Endosome Plasma Membrane Caveola Bicellular Tight Junction Cell Surface Membrane Receptor Complex
	Molecular Function	Protein Binding Oxysterol Binding Cholesterol Binding	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding Adenylate Cyclase Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Small GTPase Binding Signaling Receptor Activity Neuropeptide Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Intracellular Lipid Transport Regulation Of Intracellular Cholesterol Transport Cholesterol Homeostasis Positive Regulation Of Wound Healing Positive Regulation Of Lipoprotein Transport	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Response To Xenobiotic Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Differentiation Response To Estradiol Multicellular Organismal Response To Stress Response To Ethanol Development Of Primary Female Sexual Characteristics Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Inositol Phosphate Biosynthetic Process CAMP/PKA Signal Transduction Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Response To Reactive Oxygen Species
Pathways			NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Osteoprotegerin levels ( 25080503)	Cluster headache ( 27957625) Major depressive disorder ( 21621269) Non-word reading ( 30741946) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		66 interacting genes: APP AQP12B AQP2 AQP6 ARL13B ASZ1 ATP6AP2 BCL2L13 BIK CD53 CD74 CD79A CGRRF1 CLDN7 CLSTN3 CPLX4 EBP ERGIC3 FAM209A FFAR2 FKBP7 FRMD3 FXYD3 GJA8 GJB3 GJB5 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LEUTX LHFPL5 LIME1 LRRC59 MFF MRM1 MTIF3 MUC1 NDUFAF1 NDUFAF2 NEMP1 PDCD1LG2 PDZK1IP1 PLP1 PSCA REEP1 RHCG RNF170 SAR1A SGPL1 SLC10A1 SLC14A1 SLC14A2 SLC18A1 SLC35H1 SPINT1 SSMEM1 TMEM106C TMEM14B TMEM45B TMEM52B TMEM79 TMX2 VSIR	3 interacting genes: ADCYAP1 CALM1 ZDHHC15
Entrez ID		27346	117
HPRD ID		14343	00045
Ensembl ID		ENSG00000109084	ENSG00000078549
Uniprot IDs		Q5BJF2	A0A090N8F8 A0A994J7E9 P41586
PDB IDs			2JOD 3N94 6LPB 6M1H 6M1I 6P9Y 7JQD 8E3X
Enriched GO Terms of Interacting Partners?		Membrane Water Transport One-carbon Compound Transport Fluid Transport Protein Binding Water Channel Activity Endoplasmic Reticulum Membrane Connexin Complex Endoplasmic Reticulum Gap Junction Channel Activity Plasma Membrane B Cell Receptor Complex Water Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Mitochondrial Membrane Gap Junction Urea Transmembrane Transporter Activity Transmembrane Transport	Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Lipoprotein Transport Regulation Of Intracellular Cholesterol Transport Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Synaptic Vesicle Maturation Protein Targeting To Golgi Apparatus Positive Regulation Of Growth Hormone Secretion Rough Endoplasmic Reticulum Membrane Regulation Of Intracellular Lipid Transport Peptide Hormone Receptor Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Peptidyl-L-cysteine S-palmitoylation Regulation Of Growth Hormone Secretion Regulation Of Transport Activation Of Adenylate Cyclase Activity Titin Binding Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Calcium Channel Inhibitor Activity Oxysterol Binding Positive Regulation Of Dendrite Development Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Adenylate Cyclase Activity Protein Phosphatase Activator Activity Protein Palmitoylation Calyx Of Held Palmitoyltransferase Activity Positive Regulation Of Lyase Activity Protein-cysteine S-palmitoyltransferase Activity Positive Regulation Of Cyclase Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity
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