ADCYAP1R1

Description		ADCYAP receptor type I
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GO Annotations	Cellular Component	Endosome Plasma Membrane Caveola Bicellular Tight Junction Cell Surface Membrane Receptor Complex
	Molecular Function	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding Adenylate Cyclase Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Small GTPase Binding Signaling Receptor Activity Neuropeptide Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Response To Xenobiotic Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Differentiation Response To Estradiol Multicellular Organismal Response To Stress Response To Ethanol Development Of Primary Female Sexual Characteristics Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Inositol Phosphate Biosynthetic Process CAMP/PKA Signal Transduction Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Response To Reactive Oxygen Species
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors
Drugs
Diseases
GWAS		Cluster headache ( 27957625) Major depressive disorder ( 21621269) Non-word reading ( 30741946) Vitamin B levels in ischemic stroke ( 25147783)
Novel Interacting Genes		1 novel interacting genes: TMEM97
Interacting Genes		3 interacting genes: ADCYAP1 CALM1 ZDHHC15
Entrez ID		117
HPRD ID		00045
Ensembl ID		ENSG00000078549
Uniprot IDs		A0A090N8F8 A0A994J7E9 P41586
PDB IDs		2JOD 3N94 6LPB 6M1H 6M1I 6P9Y 7JQD 8E3X
Enriched GO Terms of Interacting Partners?		Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Lipoprotein Transport Regulation Of Intracellular Cholesterol Transport Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Synaptic Vesicle Maturation Protein Targeting To Golgi Apparatus Positive Regulation Of Growth Hormone Secretion Rough Endoplasmic Reticulum Membrane Regulation Of Intracellular Lipid Transport Peptide Hormone Receptor Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Peptidyl-L-cysteine S-palmitoylation Regulation Of Growth Hormone Secretion Regulation Of Transport Activation Of Adenylate Cyclase Activity Titin Binding Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Calcium Channel Inhibitor Activity Oxysterol Binding Positive Regulation Of Dendrite Development Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Adenylate Cyclase Activity Protein Phosphatase Activator Activity Protein Palmitoylation Calyx Of Held Palmitoyltransferase Activity Positive Regulation Of Lyase Activity Protein-cysteine S-palmitoyltransferase Activity Positive Regulation Of Cyclase Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity
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