ADCYAP1R1 and ZDHHC15

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ADCYAP1R1	ZDHHC15
Description		ADCYAP receptor type I	zDHHC palmitoyltransferase 15
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Caveola Bicellular Tight Junction Cell Surface Membrane Receptor Complex	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Postsynaptic Density Membrane Synapse Postsynapse
	Molecular Function	Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding Adenylate Cyclase Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Small GTPase Binding Signaling Receptor Activity Neuropeptide Binding	Protein Binding Zinc Ion Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity Metal Ion Binding Protein-cysteine S-stearoyltransferase Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Response To Xenobiotic Stimulus Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Differentiation Response To Estradiol Multicellular Organismal Response To Stress Response To Ethanol Development Of Primary Female Sexual Characteristics Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Inositol Phosphate Biosynthetic Process CAMP/PKA Signal Transduction Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Response To Reactive Oxygen Species	Protein Targeting To Membrane Synaptic Vesicle Maturation Peptidyl-L-cysteine S-palmitoylation Establishment Of Protein Localization Regulation Of Dendritic Spine Morphogenesis Protein Localization To Postsynapse Protein Localization To Membrane Protein Targeting To Golgi Apparatus Positive Regulation Of Dendrite Development
Pathways		NGF-independant TRKA activation G alpha (s) signalling events Glucagon-type ligand receptors
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Cluster headache ( 27957625) Major depressive disorder ( 21621269) Non-word reading ( 30741946) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		3 interacting genes: ADCYAP1 CALM1 ZDHHC15	49 interacting genes: ADCYAP1R1 ARL13B BNIP3 C14orf180 CD79A CELA2B CERCAM CFTR CLEC10A CLRN1 CREB3L1 CYB5R3 DHRSX ERGIC3 FAM241B GIMAP1 GOLGA7B GPR152 LEMD1 LEPROTL1 LHFPL5 LMNA LSMEM1 MCEMP1 MTIF3 ORMDL1 ORMDL2 PEX16 PLLP PRAF2 PVR RUSF1 SLC10A6 SMIM1 SNORC STX3 TBXA2R TMEFF2 TMEM120B TMEM128 TMEM14C TMEM222 TMEM42 TMEM52B TNFRSF10B TSNARE1 TUFM VAPB YIPF4
Entrez ID		117	158866
HPRD ID		00045	06758
Ensembl ID		ENSG00000078549	ENSG00000102383
Uniprot IDs		A0A090N8F8 A0A994J7E9 P41586	B3KY34 Q96MV8
PDB IDs		2JOD 3N94 6LPB 6M1H 6M1I 6P9Y 7JQD 8E3X
Enriched GO Terms of Interacting Partners?		Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Pituitary Adenylate Cyclase Activating Polypeptide Activity Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Adenylate Cyclase Activator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Lipoprotein Transport Regulation Of Intracellular Cholesterol Transport Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Synaptic Vesicle Maturation Protein Targeting To Golgi Apparatus Positive Regulation Of Growth Hormone Secretion Rough Endoplasmic Reticulum Membrane Regulation Of Intracellular Lipid Transport Peptide Hormone Receptor Binding Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Peptidyl-L-cysteine S-palmitoylation Regulation Of Growth Hormone Secretion Regulation Of Transport Activation Of Adenylate Cyclase Activity Titin Binding Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Calcium Channel Inhibitor Activity Oxysterol Binding Positive Regulation Of Dendrite Development Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Adenylate Cyclase Activity Protein Phosphatase Activator Activity Protein Palmitoylation Calyx Of Held Palmitoyltransferase Activity Positive Regulation Of Lyase Activity Protein-cysteine S-palmitoyltransferase Activity Positive Regulation Of Cyclase Activity Catalytic Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Transporter Activity	Membrane Membrane Docking Organelle Localization By Membrane Tethering Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Protein Binding Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex
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