PCSK1N and PCSK1

Number of citations of the paper that reports this interaction (PubMedID 11435430)
0

Data Source:
HPRD (in vitro)

		PCSK1N	PCSK1
Description		proprotein convertase subtilisin/kexin type 1 inhibitor	proprotein convertase subtilisin/kexin type 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Trans-Golgi Network Secretory Granule	Extracellular Space Membrane Transport Vesicle Secretory Granule Cytoplasmic Vesicle Secretory Granule Lumen Neuron Projection
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Response To Dietary Excess Neuropeptide Signaling Pathway Response To Cold Peptide Hormone Processing	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Insulin Processing Peptide Biosynthetic Process
Pathways			Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		Type 2 diabetes ( 30718926)	Adult body size ( 32376654) Blood protein levels ( 30072576) BMI at adiposity peak ( 31840077) Body mass index ( 22344219 29273807 28892062 25673413 24861553) Body mass index and fasting glucose (pairwise) ( 33619380) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood glucose adjusted for BMI ( 25625282) Fasting blood proinsulin levels ( 23263489) Fasting glucose ( 34059833) Glycemic traits (pregnancy) ( 23903356) Insulin-related traits (multivariate analysis) ( 32002517) Menarche (age at onset) ( 25231870) Proinsulin levels ( 21873549) Type 2 diabetes ( 32499647) Waist circumference ( 23966867)
Interacting Genes		2 interacting genes: PCSK1 RAD51	4 interacting genes: IAPP PCSK1N PMCH REN
Entrez ID		27344	5122
HPRD ID		02320	01201
Ensembl ID		ENSG00000102109	ENSG00000175426
Uniprot IDs		Q9UHG2	P29120
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitotic Recombination-dependent Replication Fork Processing Response To Glucoside DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton DNA Strand Invasion Nuclear Ubiquitin Ligase Complex DNA Recombinase Assembly Cellular Response To Cisplatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin Cellular Response To Camptothecin Response To Glycoside Insulin Processing Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea Response To Hydroxyurea Lateral Element Telomere Maintenance Via Recombination Insulin Metabolic Process ATP-dependent DNA Damage Sensor Activity Single-stranded DNA Helicase Activity Mitotic Recombination Peptide Biosynthetic Process Regulation Of DNA Damage Checkpoint DNA Polymerase Binding Reciprocal Meiotic Recombination Response To X-ray Cellular Response To Gamma Radiation Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome ATP-dependent Activity, Acting On DNA Condensed Chromosome Peptide Hormone Processing Replication Fork Processing Cellular Response To Alkaloid Meiosis I Homologous Recombination Interstrand Cross-link Repair Signaling Receptor Ligand Precursor Processing Condensed Nuclear Chromosome Male Germ Cell Nucleus Response To Gamma Radiation Chromosome Organization Involved In Meiotic Cell Cycle Peptide Metabolic Process Meiosis I Cell Cycle Process Cellular Response To Ionizing Radiation Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Identical Protein Binding Endopeptidase Activity	Feeding Behavior G Protein-coupled Receptor Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Signaling Receptor Binding Male Gonad Development Adherens Junction Disassembly Hormone Activity Neuropeptide Signaling Pathway Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Signaling Cell Communication Cell-cell Junction Disassembly Negative Regulation Of Synaptic Transmission, Dopaminergic Gonad Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Developmental Process Involved In Reproduction Tyrosine Phosphorylation Of STAT Protein Extracellular Matrix-cell Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kit Signaling Pathway Reproductive Structure Development Amylin Receptor 1 Signaling Pathway Amylin Receptor 3 Signaling Pathway Extracellular Region Amylin Receptor 2 Signaling Pathway Hormone Metabolic Process Juxtaglomerular Apparatus Development Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Protein Processing Renin-angiotensin Regulation Of Aldosterone Production Amylin Receptor Signaling Pathway Regulation Of Blood Volume By Renin-angiotensin Diapedesis Regulation Of Biological Quality Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Mast Cell Activation Response To Macrophage Colony-stimulating Factor Response To CGMP Calcitonin Family Receptor Signaling Pathway Drinking Behavior Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Lipopolysaccharide Protein Maturation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Molecule Of Bacterial Origin Cellular Developmental Process
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