ZNF638 and NELFCD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZNF638	NELFCD
Description		zinc finger protein 638	negative elongation factor complex member C/D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Membrane NELF Complex
	Molecular Function	Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	RNA Splicing Regulation Of RNA Splicing	Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription
Pathways		Transcriptional regulation of white adipocyte differentiation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Heel bone mineral density ( 30598549 28869591) Height ( 25282103 25429064 23456168 31562340) Hip circumference adjusted for BMI ( 34021172 28552196) Intelligence ( 28530673) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Pulse pressure ( 30578418 27841878) QRS interval (sulfonylurea treatment interaction) ( 27958378) Reaction time ( 29844566) Testicular germ cell tumor ( 28604728)	Mean platelet volume ( 27863252 32888494) Platelet distribution width ( 27863252)
Interacting Genes		14 interacting genes: CALCOCO2 CCDC85B EFEMP2 FHL2 HOOK2 KIFBP KRT15 KRT19 KRTAP4-12 NELFCD PLSCR1 SPP1 SUMO2 WWP1	21 interacting genes: AAMP AR ARAF ARPC4 CACNA1A CDSN DNAJA1 ENDOV EPRS1 FRMD5 GSTM4 HDAC11 MTA1 NELFA OGT PRMT5 SERF2 SMAD4 TXK UBE3A ZNF638
Entrez ID		27332	51497
HPRD ID		11736	16096
Ensembl ID		ENSG00000075292	ENSG00000101158
Uniprot IDs		A8K583 Q14966	H0UI80 Q8IXH7
PDB IDs		6SXW	5L3X 6GML 7PKS 7YCX 8JJ6 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Keratin Filament	Prostate Gland Growth Regulation Of Protein Ubiquitination Endothelial Cell Activation Circadian Regulation Of Gene Expression Seminiferous Tubule Development Positive Regulation Of RNA Metabolic Process Regulation Of Post-translational Protein Modification Rhythmic Process Cytosol Prostate Induction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Regulation Of MAPK Cascade Cellular Response To Oxygen-containing Compound Androgen Receptor Signaling Pathway Male Somatic Sex Determination Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Modification Process Regulation Of TOR Signaling Negative Regulation Of Cornification Proline-tRNA Ligase Activity Prolyl-tRNA Aminoacylation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Sperm Entry Positive Regulation Of Golgi Lumen Acidification Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Circadian Rhythm Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway DNA Endonuclease Activity, Producing 5'-phosphomonoesters Regulation Of Ubiquitin-dependent Protein Catabolic Process Enzyme Binding
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