CRCP and CALCRL

Number of citations of the paper that reports this interaction (PMID 10903324)
34

Data Source:
HPRD (in vivo)

		CRCP	CALCRL
Gene Name		CGRP receptor component	calcitonin receptor-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleoplasm DNA-directed RNA Polymerase III Complex Cytosol Plasma Membrane DNA Polymerase III Complex	Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Nucleotide Binding RNA Polymerase III Activity Calcitonin Gene-related Peptide Receptor Activity DNA-directed RNA Polymerase Activity	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G-protein Coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity
	Biological Process	Transcription From RNA Polymerase III Promoter Transcription Initiation From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Neuropeptide Signaling Pathway Gene Expression Positive Regulation Of Type I Interferon Production Innate Immune Response Defense Response To Virus	Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Regulation Of Muscle Contraction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Heart Development Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Initiation From Type 2 Promoter Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Aortic root size ( 21223598)
Protein-Protein Interactions		5 interactors: CALCRL POLR3H TCF12 VAV2 ZMIZ2	6 interactors: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Entrez ID		27297	10203
HPRD ID		12089	11809
Ensembl ID		ENSG00000241258	ENSG00000064989
Uniprot IDs		C9J2T4 O75575	Q16602
PDB IDs			3AQF 3N7P 3N7R 3N7S
Enriched GO Terms of Interacting Partners?		Cellular Response To Sucrose Stimulus Positive Regulation Of Cellular Metabolic Process Immune Response Angiogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Blood Vessel Morphogenesis Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Transcription Initiation From RNA Polymerase III Promoter Response To Sucrose Blood Vessel Development CAMP Biosynthetic Process Vasculature Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Immune System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Endocytosis Transcription, DNA-templated CAMP Metabolic Process Cellular Nitrogen Compound Metabolic Process	Receptor Internalization Receptor Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Receptor-mediated Endocytosis Regulation Of CAMP Metabolic Process Endocytosis Vascular Smooth Muscle Cell Development G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Vasculogenesis Negative Regulation Of Vascular Permeability G-protein Coupled Receptor Internalization Vasculature Development Regulation Of Vasculogenesis Vesicle-mediated Transport Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Differentiation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway CAMP Biosynthetic Process Plasma Membrane Organization Female Pregnancy Regulation Of Vascular Permeability Positive Regulation Of Vasodilation Cardiovascular System Development CAMP Metabolic Process Blood Circulation Calcium Ion Transport Cyclic Purine Nucleotide Metabolic Process Regulation Of Vasodilation Protein Localization To Membrane Cyclic Nucleotide Biosynthetic Process Smooth Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Blood Vessel Morphogenesis Endomembrane System Organization Regulation Of Signal Transduction Signal Transduction Regulation Of Heart Rate Cyclic Nucleotide Metabolic Process Response To Steroid Hormone Signaling Blood Vessel Development Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Neuropeptide Signaling Pathway
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