SRD5A2

Description		steroid 5 alpha-reductase 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Neuronal Cell Body Cell Body Fiber
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Amide Binding 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Steroid Catabolic Process Cell-cell Signaling Sex Differentiation Steroid Metabolic Process Androgen Metabolic Process Male Gonad Development Response To Xenobiotic Stimulus Biphenyl Metabolic Process Dibenzo-p-dioxin Metabolic Process Phthalate Metabolic Process Hippocampus Development Hypothalamus Development Cell Differentiation Male Genitalia Development Female Genitalia Development Response To Nutrient Levels Response To Follicle-stimulating Hormone Response To Testosterone Response To Peptide Hormone Response To Steroid Hormone Bone Development Testosterone Biosynthetic Process Response To Biphenyl
Pathways		Androgen biosynthesis
Drugs		Spironolactone Azelaic acid Dutasteride Finasteride
Diseases		46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		Estradiol levels ( 34255042) Idiopathic pulmonary fibrosis ( 29066090) Inflammatory biomarkers ( 24182552) Male-pattern baldness ( 27182965 28196072 29146897) Zinc levels ( 26025379)
Novel Interacting Genes		2 novel interacting genes: ATP5MG NCOA1
Interacting Genes		2 interacting genes: CYSRT1 GNMT
Entrez ID		6716
HPRD ID		07390
Ensembl ID		ENSG00000277893
Uniprot IDs		P31213
PDB IDs		7BW1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Glycine N-methyltransferase Activity Labyrinthine Layer Morphogenesis Sarcosine Metabolic Process S-adenosylhomocysteine Metabolic Process Cellular Response To Thyroglobulin Triiodothyronine Positive Regulation Of Female Receptivity Response To Thyroglobulin Triiodothyronine Regulation Of Thyroid Hormone Receptor Signaling Pathway Male Mating Behavior Carbon Catabolite Regulation Of Transcription Regulation Of Female Receptivity Female Mating Behavior Glycine Binding Folic Acid Binding Estrous Cycle S-adenosylmethionine Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway Progesterone Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Hypothalamus Development Nuclear Retinoic Acid Receptor Binding Proton-transporting ATP Synthase Activity, Rotational Mechanism Methionine Metabolic Process Nuclear Retinoid X Receptor Binding Regulation Of Adipose Tissue Development Mating Behavior Ovulation Cycle Purine-containing Compound Metabolic Process Proton-transporting ATP Synthase Complex S-adenosyl-L-methionine Binding Estrogen Receptor Signaling Pathway One-carbon Metabolic Process Protein-lysine-acetyltransferase Activity Proton Transmembrane Transporter Activity Purine Nucleoside Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Histone Acetyltransferase Activity Response To Progesterone Reproductive Behavior Sulfur Amino Acid Metabolic Process Establishment Of Skin Barrier Biological Process Involved In Interaction With Symbiont Cellular Response To Nutrient Nuclear Estrogen Receptor Binding Lactation Skin Epidermis Development Aspartate Family Amino Acid Metabolic Process Nuclear Receptor Binding Nucleoside Metabolic Process
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