PALD1 and ZBP1

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (pull down)

		PALD1	ZBP1
Gene Name		phosphatase domain containing, paladin 1	Z-DNA binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	DNA Binding Left-handed Z-DNA Binding RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding
	Biological Process		Biological_process Metabolic Process Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways			Regulation of innate immune responses to cytosolic DNA ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN Cytosolic sensors of pathogen-associated DNA STING mediated induction of host immune responses IRF3-mediated induction of type I IFN RIP-mediated NFkB activation via ZBP1 Innate Immune System
Drugs
Diseases
GWAS			Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		2 interactors: IRF7 ZBP1	8 interactors: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6
Entrez ID		27143	81030
HPRD ID		11419	09484
Ensembl ID		ENSG00000107719	ENSG00000124256
Uniprot IDs		Q9ULE6	Q9H171
PDB IDs			2L4M 2LNB 3EYI 4KA4
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Type I Interferon Production Positive Regulation Of Innate Immune Response Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of MRNA Stability Involved In Response To Stress Regulation Of Innate Immune Response MDA-5 Signaling Pathway Interferon-beta Production Positive Regulation Of Cytokine Production Interferon-alpha Production Negative Regulation Of Macrophage Apoptotic Process Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway CRD-mediated MRNA Stabilization Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Regulation Of Cytokine Production Establishment Of Viral Latency Positive Regulation Of Immune Response Type I Interferon Biosynthetic Process Regulation Of Monocyte Differentiation Innate Immune Response Type I Interferon Production Cellular Response To Virus Regulation Of Macrophage Apoptotic Process Regulation Of Immune Response Positive Regulation Of Immune System Process Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Interferon-alpha Production Cytokine Biosynthetic Process Positive Regulation Of Interferon-beta Production MRNA Stabilization Cytokine Metabolic Process Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Negative Regulation Of Gene Expression Defense Response Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Interferon-beta Production Cellular Response To Stress Regulation Of MRNA Stability Negative Regulation Of Leukocyte Apoptotic Process Regulation Of RNA Stability Toll-like Receptor 9 Signaling Pathway	White Fat Cell Differentiation Viral Genome Replication Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Fat Cell Differentiation Viral Life Cycle Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of Chromatin Binding
Tagcloud ?			concerted contain continuum cpeb ddx6 dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped
Tagcloud (Difference) ?			concerted contain continuum cpeb ddx6 dendritic dormant engaged fmrp foci fus granules hud masked messengers mrnas polysomes pumilio rbps repressed smaug stalled staufen synapse thousands tls transcriptome translational trapped
Tagcloud (Intersection) ?