PALD1 and IRF7

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PALD1	IRF7
Description		phosphatase domain containing paladin 1	interferon regulatory factor 7
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Signal Transduction Response To Virus Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Establishment Of Viral Latency Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Monocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Immune Response Defense Response To Virus Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways			DEx/H-box helicases activate type I IFN and inflammatory cytokines production Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Drugs
Diseases
GWAS		Lymphocyte percentage of white cells ( 27863252) Superior frontal gyrus volume ( 31530798) Type 2 diabetes ( 30130595)	Systemic lupus erythematosus ( 26502338 27399966 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989)
Interacting Genes		2 interacting genes: IRF7 ZBP1	27 interacting genes: ACADS AIP ARAF CCDC47 CREBBP EP300 GCLM INSR IRAK1 IRF3 KAT2A KAT2B LTN1 MAVS MYD88 PALD1 PIAS4 SOCS1 SOCS3 TBK1 TICAM1 TICAM2 TLK2 TP53 TRAF6 TRIM28 TRMT61B
Entrez ID		27143	3665
HPRD ID		11419	05441
Ensembl ID		ENSG00000107719	ENSG00000185507
Uniprot IDs		A0A8V8TL18 Q9ULE6	B4E1B1 M9RSF4 Q92985
PDB IDs			2O61
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Regulation Of Cytokine-mediated Signaling Pathway Left-handed Z-DNA Binding Activation Of Innate Immune Response Regulation Of MyD88-independent Toll-like Receptor Signaling Pathway Establishment Of Viral Latency Defense Response To Virus Positive Regulation Of Innate Immune Response Execution Phase Of Necroptosis MDA-5 Signaling Pathway Response To Virus Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Activation Of Immune Response Double-stranded RNA Adenosine Deaminase Activity Regulation Of Innate Immune Response Positive Regulation Of Defense Response Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Necroptotic Process Necroptotic Signaling Pathway Positive Regulation Of Programmed Necrotic Cell Death Regulation Of Interleukin-1-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Immune Response Defense Response To Symbiont Defense Response To Other Organism Regulation Of Monocyte Differentiation Regulation Of Defense Response Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Immune Response Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune System Process Regulation Of Necroptotic Process Regulation Of Myeloid Cell Apoptotic Process Response To Other Organism Regulation Of Programmed Necrotic Cell Death Immunoglobulin Mediated Immune Response Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Immune Response Pyroptotic Inflammatory Response B Cell Mediated Immunity Response To External Biotic Stimulus Type I Interferon-mediated Signaling Pathway Defense Response Defense Response To Fungus Negative Regulation Of Leukocyte Apoptotic Process Regulation Of Apoptotic Process	Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Type I Interferon Production Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Type I Interferon Production Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Interferon-mediated Signaling Pathway Positive Regulation Of Defense Response TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Lipopolysaccharide-mediated Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Transferase Activity Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Cellular Response To Molecule Of Bacterial Origin Acetyltransferase Activity Type I Interferon-mediated Signaling Pathway Regulation Of Defense Response Canonical NF-kappaB Signal Transduction MRNA Transcription Macromolecule Metabolic Process Transcription Coregulator Activity Positive Regulation Of Immune Response Histone Acetyltransferase Complex Intracellular Receptor Signaling Pathway Protein-lysine-acetyltransferase Activity Positive Regulation Of Cytokine Production Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Endolysosomal Toll-like Receptor Signaling Pathway
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