HSPB7 and PIP4K2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HSPB7	PIP4K2B
Description		heat shock protein family B (small) member 7	phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cajal Body Actin Cytoskeleton Aggresome	Nucleus Nucleoplasm Cytoplasm Autophagosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Filamin Binding	Nucleotide Binding Protein Binding ATP Binding GTP Binding Kinase Activity 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Transferase Activity Protein Homodimerization Activity Phosphatidylinositol Kinase Activity
	Biological Process	Response To Unfolded Protein Heart Development Regulation Of Heart Contraction	Lipid Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Phosphatidylinositol Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphate Biosynthetic Process Autophagosome-lysosome Fusion 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways			Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs			Fostamatinib
Diseases
GWAS		Arterial stiffness index ( 31235810) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction ( 30583798) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Systolic blood pressure ( 28739976)	Appendicular lean mass ( 33097823) Height ( 20881960 28552196 31562340)
Interacting Genes		18 interacting genes: APP BAG3 C22orf15 CEP76 DDIT4L DYNLT1 GUCD1 HSPB8 PDLIM7 PIP4K2B PLEKHF2 PRDM14 REL SF3B4 SYCE1 TCF4 TEPSIN TRIM23	17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131
Entrez ID		27129	8396
HPRD ID		13684	04463
Ensembl ID		ENSG00000173641	ENSG00000276293
Uniprot IDs		D3YTC6 Q68DG0 Q8N241 Q9UBY9	P78356
PDB IDs		8PA0 8RHA	1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H 7EM1 7EM2 7EM3 7EM4 7EM5 7EM6 7EM7 7EM8 7N80 7N81
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Aggrephagy Positive Regulation Of Autophagy Positive Regulation Of Macroautophagy Cellular Response To Unfolded Protein Positive Regulation Of Catabolic Process	Nucleus Negative Regulation Of DNA Recombination Nucleoplasm Cajal Body Regulation Of Primary Metabolic Process Regulation Of B Cell Cytokine Production Monocyte Proliferation Positive Regulation Of Interleukin-17A Production Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Macromolecule Metabolic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Identical Protein Binding Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Repair Nucleobase-containing Compound Metabolic Process DNA Metabolic Process DNA Damage Response Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleic Acid Metabolic Process Negative Regulation Of Double-strand Break Repair Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Kynureninase Activity Telomere-telomerase Complex Assembly Regulation Of DNA Metabolic Process Response To Stress Positive Regulation Of Immunoglobulin Production Double-strand Break Repair Via Nonhomologous End Joining DNA Repair Regulation Of DNA Repair DNA Recombination Positive Regulation Of Type I Hypersensitivity B Cell Affinity Maturation Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Response To Vitamin B6 Nuclear Proteasome Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Immunoglobulin Production Regulation Of Metabolic Process Eosinophil Homeostasis Positive Regulation Of Type III Hypersensitivity Macromolecule Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase CK2 Complex
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