HSPB7 and HSPB8

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		HSPB7	HSPB8
Gene Name		heat shock 27kDa protein family, member 7 (cardiovascular)	heat shock 22kDa protein 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cajal Body Actin Cytoskeleton	Intracellular Nucleus Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Protein Binding Protein C-terminus Binding Filamin Binding	Protein Kinase Activity Protein Binding Identical Protein Binding
	Biological Process	Response To Unfolded Protein Regulation Of Heart Contraction	Biological_process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: APP CEP76 FLNA HSPB8 PLEKHF2 PRDM14 REL SF3B4 SYCE1 TCF4 TRIM23	13 interactors: BAG3 CRYAB CSNK2A1 DUSP12 HSPB1 HSPB2 HSPB3 HSPB6 HSPB7 MAPK3 PRKCA QRICH1 SNCA
Entrez ID		27129	26353
HPRD ID		13684	06420
Ensembl ID		ENSG00000173641	ENSG00000152137
Uniprot IDs		Q8N241 Q9UBY9	Q9UJY1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Stem Cell Development Stem Cell Differentiation Somatic Stem Cell Maintenance Platelet Degranulation Histone H3-R26 Methylation Inner Cell Mass Cell Fate Commitment Cell Cycle Process Synaptic Growth At Neuromuscular Junction Catenin Import Into Nucleus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Collateral Sprouting In Absence Of Injury RNA Metabolic Process Maintenance Of DNA Repeat Elements Regulation Of Protein Binding Stem Cell Maintenance Gene Expression Collateral Sprouting Axon Midline Choice Point Recognition Cell Cycle Positive Regulation Of Intracellular Protein Transport Germ-line Stem Cell Maintenance Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Embryonic Hindgut Morphogenesis Inner Cell Mass Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Embryonic Genitalia Morphogenesis Axon Choice Point Recognition Regulation Of Cellular Response To Growth Factor Stimulus Platelet Activation Myoblast Fate Commitment Positive Regulation Of Gene Expression Negative Regulation Of Cell Differentiation Regulation Of Nucleocytoplasmic Transport Secretory Granule Localization Neuron Remodeling Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway See more	Response To Unfolded Protein Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Regulation Of Catalytic Activity Cell Death Death Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Response To Organic Substance Response To Interleukin-1 Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Response To Stress Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Platelet Activation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Chromosome Organization Cellular Response To Growth Factor Stimulus Response To External Stimulus Negative Regulation Of Nucleotide Metabolic Process Response To Growth Factor Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Histone Acetylation Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Endopeptidase Activity Cell Activation Negative Regulation Of Peptidase Activity Regulation Of Phosphorylation Positive Regulation Of Endothelial Cell Migration Protein Folding Regulation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Glutathione Peroxidase Activity Negative Regulation Of Apolipoprotein Binding Positive Regulation Of Dense Core Granule Biogenesis See more
Tagcloud ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb9 hsps oligodactylic performs phocomelic trap1	accordingly ala antiestrogens antiprogestins cdk2 cdks coactivators copurified cos deregulation disrupted g2 insensitive keys lysates pr probed progesterone progestin prs roscovitine s345a ser345 sp1 synchronized t47d talk transcriptionally transiently
Tagcloud (Difference) ?		apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb9 hsps oligodactylic performs phocomelic trap1	accordingly ala antiestrogens antiprogestins cdk2 cdks coactivators copurified cos deregulation disrupted g2 insensitive keys lysates pr probed progesterone progestin prs roscovitine s345a ser345 sp1 synchronized t47d talk transcriptionally transiently
Tagcloud (Intersection) ?