RILP and RAB34

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		RILP	RAB34
Description		Rab interacting lysosomal protein	RAB34, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Protein-containing Complex Ciliary Basal Body	Cytoplasm Golgi Apparatus Golgi Stack Centrosome Centriole Cytoskeleton Cilium Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Golgi Cisterna Ruffle Membrane Cell Projection Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Endosome To Lysosome Transport Protein Transport Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Protein Catabolic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Cilium Assembly Intralumenal Vesicle Formation	Protein Transport Antigen Processing And Presentation Cell Projection Organization Lysosome Localization Golgi To Plasma Membrane Protein Transport Macropinocytosis Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Cytosolic Ciliogenesis Protein Localization To Plasma Membrane Phagosome Maturation Phagosome-lysosome Fusion
Pathways		MHC class II antigen presentation	RAB geranylgeranylation
Drugs
Diseases
GWAS			Urate levels in lean individuals ( 25811787)
Interacting Genes		12 interacting genes: KPNA2 LDB2 RAB34 RAB7A RCHY1 SNF8 VPS11 VPS16 VPS18 VPS36 VPS39 VPS41	9 interacting genes: CA8 RABGAP1L RALA REP15 RILP SMAD1 SMAD2 SMAD4 TGFBR1
Entrez ID		83547	83871
HPRD ID		09706	06701
Ensembl ID		ENSG00000167705	ENSG00000109113
Uniprot IDs		Q96NA2	B4DNC0 E7ES60 P0DI83 Q96PJ7 Q9BZG1
PDB IDs		1YHN
Enriched GO Terms of Interacting Partners?		Vesicle Organization Late Endosome Membrane Vacuolar Transport Organelle Membrane Fusion Vesicle Fusion Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Endosome To Lysosome Transport Organelle Fusion Autophagy Late Endosome Membrane Fusion Intracellular Protein Transport Membrane Organization Protein Transport Lysosomal Transport Endosome Membrane Establishment Of Protein Localization Cellular Localization Vesicle-mediated Transport Endosome Intracellular Transport Intracellular Protein Localization Lysosome CORVET Complex AP-3 Adaptor Complex Establishment Of Localization In Cell Establishment Of Protein Localization To Vacuole Lysosomal Membrane Clathrin-coated Vesicle Organelle Organization Endosome Organization Protein Localization To Vacuole Catabolic Process Lysosomal HOPS Complex Endosomal Transport ESCRT II Complex Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Organelle Vesicle Tethering Complex Macroautophagy Vacuole Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Catabolic Process Cytoplasmic Vesicle Endocytic Recycling Autophagosome Phagosome Maturation Membrane Docking	I-SMAD Binding SMAD Protein Complex Heteromeric SMAD Protein Complex Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Signal Transduction Homomeric SMAD Protein Complex Activin Receptor Signaling Pathway Activin Responsive Factor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Fate Commitment Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Binding Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Trophoblast Cell Migration Response To Transforming Growth Factor Beta Roof Of Mouth Development Ubiquitin Protein Ligase Binding Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Response To Growth Factor Co-SMAD Binding Primary MiRNA Processing Secondary Palate Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Cardiac Conduction System Development Pattern Specification Process Ameboidal-type Cell Migration Regulation Of Extracellular Matrix Assembly Anterior/posterior Pattern Specification Response To Cholesterol R-SMAD Binding Positive Regulation Of Extracellular Matrix Organization Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Filopodium Assembly Embryonic Cranial Skeleton Morphogenesis Embryonic Axis Specification Endoderm Development MiRNA Processing Tube Development Neuron Fate Commitment Ventricular Septum Morphogenesis Ureteric Bud Development Transcription Regulator Complex Enzyme-linked Receptor Protein Signaling Pathway Establishment Of Protein Localization In Utero Embryonic Development Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Cell Differentiation
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