FOXD3 and POU5F1

Number of citations of the paper that reports this interaction (PMID 11891324)
37

Data Source:
HPRD (in vitro)

		FOXD3	POU5F1
Gene Name		forkhead box D3	POU class 5 homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding MiRNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Trophectodermal Cell Differentiation Embryonic Placenta Development Transcription, DNA-templated Somatic Stem Cell Maintenance Positive Regulation Of Transcription From RNA Polymerase II Promoter	Endodermal Cell Fate Specification Blastocyst Development BMP Signaling Pathway Involved In Heart Induction Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Response To Wounding Anatomical Structure Morphogenesis Regulation Of Asymmetric Cell Division Regulation Of Gene Expression Somatic Stem Cell Maintenance Positive Regulation Of Catenin Import Into Nucleus MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus Cell Fate Commitment Involved In Formation Of Primary Germ Layer Cardiac Cell Fate Determination Negative Regulation Of Gene Silencing By MiRNA Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway Regulation Of Methylation-dependent Chromatin Silencing
Pathways		Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Transcriptional regulation of pluripotent stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS			Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425 21801394)
Protein-Protein Interactions		1 interactors: POU5F1	14 interactors: AR ETS2 EWSR1 FOXD3 HMGB1 HMGB2 ITCH MNAT1 NR0B1 SOX10 SOX2 SOX8 WDR5 WWP2
Entrez ID		27022	5460
HPRD ID		07018	01252
Ensembl ID		ENSG00000187140	ENSG00000204531
Uniprot IDs		Q9UJU5	D2IYK3 M1S623 Q01860
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Heart Induction By Regulation Of Canonical Wnt Signaling Pathway BMP Signaling Pathway Involved In Heart Induction Negative Regulation Of Gene Silencing By MiRNA Regulation Of Methylation-dependent Chromatin Silencing Cardiac Cell Fate Determination BMP Signaling Pathway Involved In Heart Development Regulation Of Asymmetric Cell Division Endodermal Cell Fate Specification Regulation Of Gene Silencing By MiRNA Positive Regulation Of Catenin Import Into Nucleus MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of SMAD Protein Import Into Nucleus MRNA Transcription Endodermal Cell Fate Commitment Regulation Of SMAD Protein Import Into Nucleus Regulation Of Cell Fate Specification Regulation Of Gene Silencing Regulation Of Catenin Import Into Nucleus Regulation Of Transcription Involved In Cell Fate Commitment Regulation Of Heart Morphogenesis Cell Fate Commitment Involved In Formation Of Primary Germ Layer Regulation Of Cell Fate Commitment Organ Induction Endodermal Cell Differentiation Developmental Induction Regulation Of Organ Formation Cell Fate Determination Endoderm Formation Somatic Stem Cell Maintenance BMP Signaling Pathway Endoderm Development Positive Regulation Of Protein Import Into Nucleus Cell Fate Specification Blastocyst Development Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Formation Of Primary Germ Layer Cardiocyte Differentiation Stem Cell Maintenance Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Regulation Of Organ Morphogenesis Gastrulation Regulation Of Protein Localization To Nucleus Regulation Of Chromosome Organization Regulation Of Nucleocytoplasmic Transport Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Transport Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Reproductive Structure Development Reproductive System Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Apoptotic Process Cellular Nitrogen Compound Metabolic Process Sex Differentiation Regulation Of Cell Death System Development RNA Metabolic Process Nitrogen Compound Metabolic Process Developmental Process Involved In Reproduction Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Base-excision Repair, DNA Ligation Cellular Macromolecule Biosynthetic Process Male Sex Differentiation Positive Regulation Of Cell Proliferation Multicellular Organismal Development Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Apoptotic Process Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Proliferation
Tagcloud ?		abundantly border commences complexity crest dimethylation distinguishing methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox10 sox9 spatiotemporally specification stationary temporally unexpected	catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Difference) ?		abundantly border commences complexity crest dimethylation distinguishing methyltransferase methyltransferases migratory msx1 multipotent neural neurepithelium nevertheless nsd3 plate precursors premigratory requirement revealing snail2 sox10 sox9 spatiotemporally specification stationary temporally unexpected	catalyze chip cofactors confirms demethylase demethylation depletion differentiated dnmt3a enhancer fact h3k9me2 identifies incompletely jmjd1c nanog newly nucleosome oct4 opposes pluripotency recruitment recruits reprogram sequentially stepwise synthesized timecourse whereby
Tagcloud (Intersection) ?