CNST and GJB2

Number of citations of the paper that reports this interaction (PubMedID 19864490)
62

Data Source:
BioGRID (pull down)

		CNST	GJB2
Description		consortin, connexin sorting protein	gap junction protein beta 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex	Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	Protein Binding Phosphatase Binding Connexin Binding	Gap Junction Channel Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Positive Regulation Of Golgi To Plasma Membrane Protein Transport	Cell Communication Cell-cell Signaling Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways			Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane
Drugs
Diseases			Deafness, autosomal recessive Keratitis-ichthyosis-deafness syndrome Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis Deafness, autosomal dominant Palmoplantar keratoderma with deafness
GWAS		Antisaccade task score ( 31596458)	Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		13 interacting genes: EWSR1 GJA1 GJB1 GJB2 GJB3 GJB6 GJC1 PIGP POT1 PPP1CA PPP1CC ROPN1 SNCA	44 interacting genes: AMIGO1 APLNR AQP6 ARL13B CAV1 CD14 CNST CREB3 EBP ERGIC3 FAM209A FFAR2 GJA5 GJA8 GJB1 GJB6 GPR152 GPR42 HSD17B13 KCNK5 KLRC1 LHFPL5 LMNA LRRC4C MFSD6 MS4A6E PEX12 PLEKHB2 SAR1A SHISAL1 SLC10A6 SLC18A1 SLC30A2 SSMEM1 TBXA2R TEX29 TIMMDC1 TLCD4 TM2D2 TMEM106A TMEM237 TMEM31 TMX2 TRHR
Entrez ID		163882	2706
HPRD ID		08718	00413
Ensembl ID		ENSG00000162852	ENSG00000165474
Uniprot IDs		Q6PJW8	H9U1J4 P29033
PDB IDs			2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG 6UVR 6UVS 6UVT 7QEO 7QEQ 7QER 7QES 7QET 7QEU 7QEV 7QEW 7QEY 8Q9Z 8QA0 8QA1 8QA2 8QA3
Enriched GO Terms of Interacting Partners?		Connexin Complex Gap Junction Channel Activity Gap Junction Assembly Gap Junction Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Cell-cell Junction Assembly Cell-cell Signaling Cell-cell Junction Organization Signaling Cell Communication Anchoring Junction Cell Junction Organization Cell Junction Assembly Gap Junction-mediated Intercellular Transport PTW/PP1 Phosphatase Complex Cardiac Muscle Tissue Development Atrial Cardiac Muscle Cell Action Potential Intercellular Transport Presynapse Cell Communication By Electrical Coupling Involved In Cardiac Conduction Striated Muscle Tissue Development Cell Communication Involved In Cardiac Conduction Transmembrane Transport Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding Cellular Component Assembly Muscle Tissue Development Photoperiodism Entrainment Of Circadian Clock Maintenance Of Blood-brain Barrier Chromosome, Telomeric Region Cardiac Muscle Cell Action Potential Involved In Contraction Response To Electrical Stimulus Cardiac Muscle Cell Action Potential Beta-tubulin Binding Cell Junction Alpha-tubulin Binding Kinesin Binding Intercalated Disc Postsynapse Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Glycogen Metabolic Process	Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Gap Junction Assembly Protein Binding Plasma Membrane Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Vasoconstriction Connexin Binding Atrioventricular Valve Development Gap Junction-mediated Intercellular Transport Regulation Of Gap Junction Assembly Intercellular Transport G Protein-coupled Receptor Activity Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Muscle System Process Transmembrane Transport Regulation Of Vasoconstriction
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