GH1 and BTRC

Number of citations of the paper that reports this interaction (PMID 17500058)
22

Data Source:
BioGRID (pull down)

		GH1	BTRC
Gene Name		growth hormone 1	beta-transducin repeat containing E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Growth Hormone Receptor Binding Prolactin Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity
	Biological Process	Positive Regulation Of Receptor Internalization JAK-STAT Cascade Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Glucose Transport Response To Estradiol Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of MAP Kinase Activity Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Bone Maturation	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Circadian Rhythm Viral Process Wnt Signaling Pathway Protein Ubiquitination Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Cell Cycle Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Organic Cyclic Compound
Pathways		Peptide hormone metabolism Nuclear signaling by ERBB4 Synthesis, secretion, and deacylation of Ghrelin Cytokine Signaling in Immune system Signaling by ERBB4 Prolactin receptor signaling Growth hormone receptor signaling	Signaling by the B Cell Receptor (BCR) Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt Regulation of PLK1 Activity at G2/M Transition Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling S33 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation Prolactin receptor signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Host Interactions of HIV factors AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Regulation of APC/C activators between G1/S and early anaphase Signaling by ERBB4 APC/C-mediated degradation of cell cycle proteins Signaling by Interleukins deletions in the AMER1 gene destabilize the destruction complex AMER1 mutants destabilize the destruction complex Interleukin-1 signaling Mitotic G2-G2/M phases Adaptive Immune System Antigen processing: Ubiquitination & Proteasome degradation APC truncation mutants have impaired AXIN binding HIV Infection G2/M Transition deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Class I MHC mediated antigen processing & presentation Vpu mediated degradation of CD4 Cytokine Signaling in Immune system Cell Cycle, Mitotic Nuclear signaling by ERBB4 TCF dependent signaling in response to WNT Activation of NF-kappaB in B cells SCF-beta-TrCP mediated degradation of Emi1 Regulation of mitotic cell cycle deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by Hedgehog Degradation of GLI1 by the proteasome Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: BTRC GHR PRLR SHC1	72 interactors: AGO2 AMER1 ATF4 AXIN1 BHLHE40 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXO5 FBXW11 FOXO3 GH1 GHR GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 JUP KDR MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB PCDH8 PDCD4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA SKP1 SMAD3 SMAD4 SMURF2 SP1 SUFU TACC1 TAZ TFAP4 TIAM1 TP63 TRIM9 TSPAN15 UBE2D2 UBE2D3 UBE2R2 UBQLN2 UHRF1 USP37 WEE1 YAP1 ZC3H12A
Entrez ID		2688	8945
HPRD ID		00751	04596
Ensembl ID		ENSG00000259384	ENSG00000166167
Uniprot IDs		B1A4G6 B1A4G7 B1A4G9 B1A4H0 P01241	B2R8L3 B7Z3H4 Q68DS0 Q9Y297
PDB IDs		1A22 1AXI 1BP3 1HGU 1HUW 1HWG 1HWH 1KF9 3HHR	1P22 2P64
Enriched GO Terms of Interacting Partners?		Activation Of JAK2 Kinase Activity Positive Regulation Of Transferase Activity Activation Of Janus Kinase Activity Positive Regulation Of Protein Modification Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Growth Hormone Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cellular Response To Growth Hormone Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Growth Hormone Positive Regulation Of Catalytic Activity JAK-STAT Cascade Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Cellular Response To Organonitrogen Compound Regulation Of Intracellular Signal Transduction Response To Peptide Positive Regulation Of Kinase Activity Positive Regulation Of JAK-STAT Cascade Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Protein Metabolic Process Regulation Of JAK-STAT Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mammary Gland Epithelium Development Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Activation Of MAPK Activity Enzyme Linked Receptor Protein Signaling Pathway Phosphate-containing Compound Metabolic Process Response To Hormone Peptidyl-amino Acid Modification Mammary Gland Development Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Regulation Of Protein Phosphorylation	Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Response To Growth Factor Cell Communication G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Signaling Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Regulation Of Signaling Programmed Cell Death Regulation Of Transcription, DNA-templated Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Signal Transduction Cellular Response To Stimulus Cell Cycle Process Regulation Of Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus
Tagcloud ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish hybrid interspecies library linkage locations loci map meiotic nf1 p4hb tp53 unresolved	aggregate austere bias biases chamber clinics error homes humidity individually instruments isolate meter meters minutes poc rank reagent responders signed spiked static stressed stresses strip strips tenney unstressed wilcoxon
Tagcloud (Difference) ?		anchor anchorage artificial assign bac backcross bacs bands bovine bta19 centromere chrnb1 chromosomes colour construct cryb1 fish hybrid interspecies library linkage locations loci map meiotic nf1 p4hb tp53 unresolved	aggregate austere bias biases chamber clinics error homes humidity individually instruments isolate meter meters minutes poc rank reagent responders signed spiked static stressed stresses strip strips tenney unstressed wilcoxon
Tagcloud (Intersection) ?