GFPT1 and DSCAM

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		GFPT1	DSCAM
Description		glutamine--fructose-6-phosphate transaminase 1	DS cell adhesion molecule
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Extracellular Region Plasma Membrane Membrane Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Glutamine-fructose-6-phosphate Transaminase (isomerizing) Activity Protein Binding Transaminase Activity Transferase Activity Carbohydrate Derivative Binding	Protein Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding Netrin Receptor Binding
	Biological Process	Fructose 6-phosphate Metabolic Process UDP-N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process Energy Reserve Metabolic Process Protein N-linked Glycosylation Circadian Regulation Of Gene Expression Rhythmic Process Carbohydrate Derivative Metabolic Process Carbohydrate Derivative Biosynthetic Process	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Nervous System Development Axon Guidance Synapse Assembly Central Nervous System Development Locomotory Behavior Retina Layer Formation Social Behavior Synaptic Transmission, Glutamatergic Netrin-activated Signaling Pathway Positive Regulation Of Phosphorylation Dendrite Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Post-embryonic Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Dendritic Spine Development Dendrite Self-avoidance
Pathways		XBP1(S) activates chaperone genes Defective GFPT1 causes CMSTA1 Synthesis of UDP-N-acetyl-glucosamine	DSCAM interactions DSCAM interactions
Drugs
Diseases
GWAS		Whole brain grey matter density ( 31530798)	Adult body size ( 32376654) Anxiety in major depressive disorder ( 24047446) Blood protein levels ( 30072576) Fasting plasma glucose ( 31170924) Feeling nervous ( 29500382) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota relative abundance (Prevotella) ( 33208821) Hallux valgus ( 32131869) Intracranial aneurysm ( 30823506) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Mild to moderate chronic kidney disease ( 31178898) Neutrophil count ( 21507922) Non-small cell lung cancer (survival) ( 21079520) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia x sex interaction ( 34099189) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Systemising ( 31508503) Tuberculosis ( 24057671) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		3 interacting genes: DSCAM MAPK8 PRKCA	157 interacting genes: ACO1 ACTN1 ACTN4 AFDN AMOTL2 AP2A1 AP2B1 APC2 ARCN1 ARIH2 ASTN1 ATP5F1B ATP6V1B2 ATRX BFSP1 BICD1 BTBD1 CADPS CAMK2A CAP2 CEP63 CFAP91 CIAO2B CIT CLTC CLU COG1 COG4 COPS5 CPNE5 CRTAC1 CSNK2B CUL9 CXXC5 DIP2A DLG1 DLG2 DLG4 DNAJA2 DPYSL2 DST DYNC1H1 DYRK1A EEF2 EIF3C ENC1 EYA3 FLNB GFAP GFPT1 GLUL GNPTAB GPRASP1 GUF1 HLA-A HNRNPF IFT122 IFT88 INTS8 IQGAP1 IST1 KALRN KCNN1 KDM4C KHDRBS1 KIF21A KIF3A KIF5A KIFC3 KLHL4 KPNB1 KRT222 KRT83 LARS1 LDB1 LIMK1 LMO2 LNX1 MACF1 MAGI2 MAGI3 MAP3K11 MAP4K4 MAT2A MERTK METAP1 METAP2 MITD1 MNAT1 MORF4L2 MPRIP MTA3 MTMR10 NAPA NAPB NCK1 NEFL NEFM NF2 NOMO2 NUP43 PAK1 PAX6 PDE4DIP PDLIM5 PIH1D2 PLEC POLDIP2 POLR3B PPP1R16B PRPF8 PSMD2 PTPN13 RAPGEF4 RCBTB1 RILPL1 ROBO1 RTL10 RUFY2 RUFY3 S100A10 SACS SDHA SEMA4D SEPTIN2 SGSM3 SHTN1 SIPA1L1 SKIL SOS2 SPTBN1 STAG1 STAT3 SUPT5H SUPV3L1 SYNE1 SYNGAP1 TARS3 TFIP11 TRIM37 TRIP11 TTC17 TTC7B UBA3 UQCRC1 USP11 VIM VPS54 WARS1 WASHC4 WDR13 WDR59 XRN2 ZBTB43 ZBTB47 ZNF202 ZNF365
Entrez ID		2673	1826
HPRD ID		00702	03953
Ensembl ID		ENSG00000198380	ENSG00000171587
Uniprot IDs		Q06210	O60469
PDB IDs		2V4M 2ZJ3 2ZJ4 6R4E 6R4F 6R4G 6R4H 6R4I 6R4J 6SVM 6SVO 6SVP 6SVQ 6ZMJ 6ZMK 7NDL	6ZR7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Development Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of MRNA Stability Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Response To Reactive Oxygen Species Enzyme Binding Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Regulation Of RNA Stability Response To Mechanical Stimulus Protein Serine/threonine Kinase Activity Protein Kinase C Signaling JUN Kinase Activity JUN Phosphorylation Histone Deacetylase Regulator Activity Basal Dendrite Histone H3K9ac Reader Activity Negative Regulation Of DNA Damage Checkpoint P-TEFb Complex Binding Histone H4 Reader Activity Histone H4K5ac Reader Activity Histone H3K27ac Reader Activity Histone H4K8ac Reader Activity Histone H4K16ac Reader Activity Histone H4K12ac Reader Activity Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Desmosome Assembly RNA Polymerase II C-terminal Domain Binding Positive Regulation Of Nervous System Development Cell Junction Assembly Neuron Projection Morphogenesis Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Cellular Component Organization Cell Projection Morphogenesis Netrin-activated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Axon Extension Involved In Axon Guidance Dendrite Self-avoidance Camera-type Eye Photoreceptor Cell Differentiation	Cytoskeleton Organelle Organization Cytoplasm Cytoskeleton Organization Regulation Of Cellular Component Organization Cytosol Regulation Of Neuron Projection Development Positive Regulation Of Axonogenesis Intracellular Protein Localization Regulation Of Cell Projection Organization Cellular Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Axonogenesis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nervous System Development Supramolecular Fiber Organization Cell Projection Actin Filament Binding Protein Binding Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Positive Regulation Of Neurogenesis Establishment Of Protein Localization Identical Protein Binding Positive Regulation Of Cell Projection Organization Regulation Of Neurogenesis Epithelial Cell Development Protein Transport Postsynaptic Density Retrograde Axonal Transport Intracellular Transport Microtubule-based Process Positive Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport Actin Binding Cytoskeleton-dependent Intracellular Transport Intermediate Filament Developmental Process Neuron Projection Microtubule Structural Constituent Of Cytoskeleton Microtubule Cytoskeleton Organization Intermediate Filament Organization Transport Along Microtubule Axon Intermediate Filament Cytoskeleton Cadherin Binding
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