GFPT1

Description		glutamine--fructose-6-phosphate transaminase 1
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	Glutamine-fructose-6-phosphate Transaminase (isomerizing) Activity Protein Binding Transaminase Activity Transferase Activity Carbohydrate Derivative Binding
	Biological Process	Fructose 6-phosphate Metabolic Process UDP-N-acetylglucosamine Metabolic Process UDP-N-acetylglucosamine Biosynthetic Process Energy Reserve Metabolic Process Protein N-linked Glycosylation Circadian Regulation Of Gene Expression Rhythmic Process Carbohydrate Derivative Metabolic Process Carbohydrate Derivative Biosynthetic Process
Pathways		XBP1(S) activates chaperone genes Defective GFPT1 causes CMSTA1 Synthesis of UDP-N-acetyl-glucosamine
Drugs
Diseases
GWAS		Whole brain grey matter density ( 31530798)
Novel Interacting Genes		2 novel interacting genes: BRD4 MRPS5
Interacting Genes		3 interacting genes: DSCAM MAPK8 PRKCA
Entrez ID		2673
HPRD ID		00702
Ensembl ID		ENSG00000198380
Uniprot IDs		Q06210
PDB IDs		2V4M 2ZJ3 2ZJ4 6R4E 6R4F 6R4G 6R4H 6R4I 6R4J 6SVM 6SVO 6SVP 6SVQ 6ZMJ 6ZMK 7NDL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Development Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Cell Adhesion Regulation Of Cell Development Positive Regulation Of Cell Differentiation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of MRNA Stability Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Leukocyte Differentiation Response To Reactive Oxygen Species Enzyme Binding Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Regulation Of RNA Stability Response To Mechanical Stimulus Protein Serine/threonine Kinase Activity Protein Kinase C Signaling JUN Kinase Activity JUN Phosphorylation Histone Deacetylase Regulator Activity Basal Dendrite Histone H3K9ac Reader Activity Negative Regulation Of DNA Damage Checkpoint P-TEFb Complex Binding Histone H4 Reader Activity Histone H4K5ac Reader Activity Histone H3K27ac Reader Activity Histone H4K8ac Reader Activity Histone H4K16ac Reader Activity Histone H4K12ac Reader Activity Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Desmosome Assembly RNA Polymerase II C-terminal Domain Binding Positive Regulation Of Nervous System Development Cell Junction Assembly Neuron Projection Morphogenesis Positive Regulation Of T-helper 17 Cell Lineage Commitment Positive Regulation Of Cellular Component Organization Cell Projection Morphogenesis Netrin-activated Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Axon Extension Involved In Axon Guidance Dendrite Self-avoidance Camera-type Eye Photoreceptor Cell Differentiation
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