GFPT1

Gene Name		glutamine--fructose-6-phosphate transaminase 1
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Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Glutamine-fructose-6-phosphate Transaminase (isomerizing) Activity Amino Acid Binding Carbohydrate Binding
	Biological Process	Fructose 6-phosphate Metabolic Process Glucosamine Biosynthetic Process UDP-N-acetylglucosamine Biosynthetic Process Energy Reserve Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Glutamine Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Sucrose Carbohydrate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Insulin Stimulus Circadian Regulation Of Gene Expression Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Glycogen Biosynthetic Process Protein Homotetramerization
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) XBP1(S) activates chaperone genes Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein IRE1alpha activates chaperones Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Unfolded Protein Response (UPR) Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Synthesis of UDP-N-acetyl-glucosamine Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: MAPK8 PRKCA
Entrez ID		2673
HPRD ID		00702
Ensembl ID		ENSG00000198380
Uniprot IDs		Q06210
PDB IDs		2V4M 2ZJ3 2ZJ4
Enriched GO Terms of Interacting Partners?		Peptidyl-threonine Phosphorylation Peptidyl-serine Phosphorylation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Dense Core Granule Biogenesis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Histone H3-T6 Phosphorylation Response To Light Stimulus Apoptotic Signaling Pathway Response To Radiation JUN Phosphorylation Positive Regulation Of Deacetylase Activity Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Cellular Response To Growth Factor Stimulus Response To Growth Factor Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Establishment Of Protein Localization Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Cellular Response To Nitric Oxide Desmosome Organization Regulation Of Protein Localization Innate Immune Response Response To Nitric Oxide Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Blood Vessel Endothelial Cell Migration Peptidyl-amino Acid Modification Regulation Of Lipopolysaccharide-mediated Signaling Pathway Apoptotic Process Negative Regulation Of Cell Death Negative Regulation Of Adenylate Cyclase Activity Cellular Response To Reactive Nitrogen Species Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Programmed Cell Death Negative Regulation Of Lyase Activity Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Cell Death Death
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