ITGB1BP2 and TKT

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ITGB1BP2	TKT
Description		integrin subunit beta 1 binding protein 2	transketolase
Image		No pdb structure
GO Annotations	Cellular Component	Z Disc	Nucleoplasm Cytoplasm Peroxisome Endoplasmic Reticulum Membrane Cytosol Nuclear Body Vesicle Extracellular Exosome
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Metal Ion Binding	Magnesium Ion Binding Transketolase Activity Calcium Ion Binding Protein Binding Transferase Activity Transketolase Or Transaldolase Activity Thiamine Pyrophosphate Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Signal Transduction Muscle Organ Development Centrosome Duplication	Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Glyceraldehyde-3-phosphate Metabolic Process Regulation Of Growth Glyceraldehyde-3-phosphate Biosynthetic Process D-xylulose 5-phosphate Biosynthetic Process
Pathways			Insulin effects increased synthesis of Xylulose-5-Phosphate Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs			Copper
Diseases
GWAS			A body shape index ( 34021172) Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) QRS duration ( 27577874 27659466 30012220) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		14 interacting genes: HSP90AA1 HSP90AB1 ITGB1 PPHLN1 PUM3 RARA RARG SGCA SH3GLB1 STAG2 TKT TTN UGDH WASL	8 interacting genes: CEBPA FNDC3B ITGB1BP2 LINC01554 MYOC SERPINB5 SQSTM1 TERF1
Entrez ID		26548	7086
HPRD ID		02271	06001
Ensembl ID		ENSG00000147166	ENSG00000163931
Uniprot IDs		Q9UKP3	P29401 V9HWD9
PDB IDs			3MOS 3OOY 4KXU 4KXV 4KXW 4KXX 4KXY 6HA3 6HAD 6RJB 8WA8 8WA9 8WAA
Enriched GO Terms of Interacting Partners?		Trachea Cartilage Development Glandular Epithelial Cell Development Telomerase Holoenzyme Complex Assembly Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Growth Plate Cartilage Development Regulation Of Protein Localization Melanosome Protein Kinase Regulator Activity Columnar/cuboidal Epithelial Cell Development Embryonic Camera-type Eye Development Regulation Of Plasma Membrane Organization Chaperone-mediated Protein Complex Assembly Chromosome Organization Telomere Maintenance Via Telomerase Histone Deacetylase Binding DNA Polymerase Binding Cartilage Development Involved In Endochondral Bone Morphogenesis Retinoic Acid Receptor Signaling Pathway Face Development Protein Homodimerization Activity Axonal Growth Cone RNA-templated DNA Biosynthetic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Protein-containing Complex Telomere Maintenance Via Telomere Lengthening Protein Folding Chaperone Complex Negative Regulation Of Cartilage Development Skeletal Muscle Contraction Positive Regulation Of Protein Localization ATP-dependent Protein Folding Chaperone Cardiac Muscle Cell Differentiation Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Folding Muscle Contraction Positive Regulation Of Nitric Oxide Metabolic Process Extracellular Exosome Protein Tyrosine Kinase Binding Tau Protein Binding Supramolecular Fiber Organization Sarcomere Organization Regulation Of Myelination Anatomical Structure Morphogenesis CTP Binding DATP Binding Cellular Response To Heat Myoblast Fate Specification Cardiocyte Differentiation	Fat Cell Proliferation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Energy Homeostasis Receptor Tyrosine Kinase Binding Skeletal Muscle Hypertrophy Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Response To Vitamin B2 C/EBP Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Brown Fat Cell Proliferation Amphisome CHOP-C/EBP Complex
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