SP8 and ZNF519

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		SP8	ZNF519
Description		Sp8 transcription factor	zinc finger protein 519
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Embryonic Limb Morphogenesis	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways			Generic Transcription Pathway Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Bipolar I disorder ( 20386566) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Prostate cancer ( 23535732) Response to statin therapy ( 20339536) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Macrovascular complications in type 2 diabetes ( 33430853) Metabolite levels ( 23823483) Negative urgency ( 30718321)
Interacting Genes		3 interacting genes: HEYL ZNF273 ZNF519	1 interacting genes: SP8
Entrez ID		221833	162655
HPRD ID		12208	15816
Ensembl ID		ENSG00000164651	ENSG00000175322
Uniprot IDs		A8K350 Q8IXZ3	Q8TB69
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding AF-1 Domain Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Transcription By RNA Polymerase II Aortic Valve Morphogenesis Glomerulus Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Atrioventricular Valve Morphogenesis Mesenchymal Cell Development Cellular Response To BMP Stimulus Pulmonary Valve Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Nephron Tubule Development Renal Tubule Development Proximal Tubule Development Cardiac Ventricle Morphogenesis Regulation Of Androgen Receptor Signaling Pathway Endocardial Cushion Morphogenesis Circulatory System Development Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ventricular Septum Morphogenesis Regulation Of RNA Metabolic Process Heart Valve Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Cell Differentiation Outflow Tract Morphogenesis Negative Regulation Of DNA-binding Transcription Factor Activity Kidney Epithelium Development Cardiac Septum Morphogenesis	Limb Morphogenesis Proximal/distal Pattern Formation Dorsal/ventral Pattern Formation Embryonic Limb Morphogenesis
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