FBXL4 and GP1BA

Data Source: HiPPIP (Novel)

		FBXL4	GP1BA
Name		F-box and leucine rich repeat protein 4	glycoprotein Ib platelet subunit alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Cytosol Membrane Nuclear Speck SCF Ubiquitin Ligase Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Exosome Glycoprotein Ib-IX-V Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding Thrombin-activated Receptor Activity Signaling Receptor Activity
	Biological Process	Autophagy Of Mitochondrion Mitophagy Ubiquitin-dependent Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Mitophagy	Cell Morphogenesis Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Regulation Of Blood Coagulation Megakaryocyte Development Fibrinolysis Release Of Sequestered Calcium Ion Into Cytosol Thrombin-activated Receptor Signaling Pathway
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs		None	Ibuprofen Egaptivon pegol liposomal prostaglandin E1 Dexibuprofen
Diseases		None	Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Chronotype ( 30696823 ) Depression ( 29700475 ) Experiencing mood swings ( 29500382 ) Feeling nervous ( 29500382 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Major depressive disorder ( 27479909 ) Metabolite levels ( 23823483 ) Neurociticism ( 29500382 ) Regular attendance at a religious group ( 29970889 )	Blood protein levels ( 30072576 ) Keratoconus ( 33649486 ) Mean platelet volume ( 27863252 32888494 ) Platelet count ( 20139978 22139419 27863252 29403010 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 )
Novel Interactors		3 novel interactors: GP1BA MAP3K7 RXRG	1 novel interactors: FBXL4
Interacting Genes		3 interacting genes: BNIP3 BNIP3L SKP1	17 interacting genes: CTSG DDIT3 F11 F12 F2 FLNA FLNB GP5 GP9 ITGAM KNG1 OSGEP PIK3R1 SELP TPST1 VWF YWHAZ
Entrez ID		26235	2811
HPRD ID		05738	01976
Ensembl ID		ENSG00000112234	ENSG00000185245
Uniprot IDs		Q9UKA2	L7UYB8 P07359
PDB IDs		Not available	1GWB 1M0Z 1M10 1OOK 1P8V 1P9A 1QYY 1SQ0 1U0N 2BP3 3P72 3PMH 4C2A 4C2B 4CH2 4CH8 4MGX 4YR6 6XFQ 8WE2 8WF6 8WFS
GO Terms Enriched among Interactors		Cellular Response To Decreased Oxygen Levels Mitochondrial Protein Catabolic Process Positive Regulation Of Macroautophagy Cellular Response To Hypoxia Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Cellular Response To Oxygen Levels Positive Regulation Of Autophagy Protein Catabolic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Regulation Of Macroautophagy Positive Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Membrane Permeability Apoptotic Process Response To Hypoxia Cell Death Response To Decreased Oxygen Levels Programmed Cell Death Regulation Of Autophagy Of Mitochondrion Response To Oxygen Levels Regulation Of Mitochondrial Membrane Permeability Macromolecule Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Catabolic Process Mitochondrial Membrane Organization Protein Metabolic Process Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia F-box Domain Binding I-kappaB Phosphorylation Linear Polyubiquitin Binding Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Endoplasmic Reticulum-autophagosome Adaptor Activity Cul7-RING Ubiquitin Ligase Complex Autophagic Cell Death Glycoprotein Ib-IX-V Complex Thrombin-activated Receptor Activity Catabolic Process Mitochondrial Outer Membrane	Regulation Of Platelet Activation Coagulation Blood Coagulation Hemostasis Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Regulation Of Body Fluid Levels Glycoprotein Ib-IX-V Complex Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Coagulation Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Heparin Binding Protein Maturation Regulation Of Fibrinolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Extracellular Exosome Megakaryocyte Development Calcium Ion Transmembrane Import Into Cytosol Extracellular Space Defense Response To Symbiont Positive Regulation Of Fibrinolysis Defense Response To Other Organism Response To Other Organism Serine-type Peptidase Activity Regulation Of Biological Quality Regulation Of Wound Healing Cell Adhesion Serine-type Endopeptidase Activity Regulation Of Protein Localization To Nucleus Response To External Biotic Stimulus Regulation Of Response To Wounding Defense Response Protein Metabolic Process Regulation Of Cell Activation Regulation Of Multicellular Organismal Process Cell Killing Myeloid Cell Development Calcium Ion Transmembrane Transport Platelet Activation Neutrophil-mediated Killing Of Bacterium Extracellular Matrix Leukocyte Mediated Cytotoxicity Calcium Ion Transport Negative Regulation Of Multicellular Organismal Process