INTS1 and DEAF1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		INTS1	DEAF1
Description		integrator complex subunit 1	DEAF1 transcription factor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Nuclear Membrane Integrator Complex INTAC Complex	Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Blastocyst Growth Inner Cell Mass Cell Proliferation Embryo Implantation SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II U2 SnRNA 3'-end Processing Negative Regulation Of Apoptotic Process RNA Polymerase II Transcription Initiation Surveillance	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Germ Cell Development Nervous System Development Visual Learning Anatomical Structure Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Skeletal System Development
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Executive inhibition (Stroop WIT and CIT) in attention deficit hyperactivity disorder ( 28416812)
Interacting Genes		4 interacting genes: CTDP1 DEAF1 MTNR1B RNF10	23 interacting genes: AIMP2 ASCC2 CDC37 CDKN1A CDKN2A CEP76 FHL1 FXR1 FXR2 GSK3A GSK3B HRAS INTS1 LMO4 PELI2 PIN1 PPP1CA PPP1CC RAD23B RIDA TK1 XRCC5 XRCC6
Entrez ID		26173	10522
HPRD ID		10899	04027
Ensembl ID		ENSG00000164880	ENSG00000177030
Uniprot IDs		Q8N201	A0A804HIS1 O75398
PDB IDs		7CUN 7PKS 7YCX 8RBX 8RBZ 8RC4 8YJB	2JW6 4A24 5UWW
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of System Process Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep TFIIF-class Transcription Factor Complex Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Negative Regulation Of Schwann Cell Proliferation	Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Cytosol Regulation Of Phosphorus Metabolic Process Cellular Response To Gamma Radiation Regulation Of Phosphorylation Oncogene-induced Cell Senescence Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Catalytic Activity Postsynapse Regulation Of Protein Phosphorylation Response To Gamma Radiation Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Metabolic Process Glycogen Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA End Binding Ku70:Ku80 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Cell Development Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Presynapse Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Kinase Activity DNA-dependent Protein Kinase Complex Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process
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