RSL1D1 and USP25

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RSL1D1	USP25
Description		ribosomal L1 domain containing 1	ubiquitin specific peptidase 25
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GO Annotations	Cellular Component	Nucleus Chromosome Nucleolus Cytosol Cilium Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Cadherin Binding MRNA 5'-UTR Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin-like Protein Peptidase Activity Ubiquitin Protein Ligase Binding SUMO Binding Ubiquitin Binding ATPase Binding Deubiquitinase Activity
	Biological Process	Osteoblast Differentiation Regulation Of Protein Localization Regulation Of Apoptotic Process Regulation Of Cellular Senescence	Proteolysis Protein Deubiquitination Regulation Of Protein Stability Cellular Response To Oxidative Stress Protein Modification Process Interleukin-17A-mediated Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Response To Oxidative Stress Negative Regulation Of Interleukin-17-mediated Signaling Pathway Negative Regulation Of ERAD Pathway
Pathways			Ub-specific processing proteases
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Testicular germ cell tumor ( 26503584 28604728 28604732)	Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Serum alkaline phosphatase levels ( 33547301) Severe autoimmune type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		12 interacting genes: ADARB1 ADH6 APP CAB39 CEBPA CSNK2A1 IL7R MDM2 PTEN TP53 USP25 USP7	37 interacting genes: ACTA1 ARMC8 CDC73 CNTN1 EIF4A3 FBXL17 FLNC GAPDH GDI1 MAGEB4 MAVS MID2 MT2A NAP1L3 PAX6 PUS10 RAD23A RAD23B RPS10-NUDT3 RSL1D1 SENP1 SKIL SNRNP70 SUMO1 SUMO2 SUMO3 SYK TMEM43 TNKS TNKS2 TUBB UBC UBE2I VPS45 YARS1 ZNF426 ZNF841
Entrez ID		26156	29761
HPRD ID		10897	05296
Ensembl ID		ENSG00000171490	ENSG00000155313
Uniprot IDs		O76021	Q9UHP3
PDB IDs		8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL2 8FL6 8FLA 8FLD 8INE 8INF 8IPX 8IPY 8IR3	2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?		Regulation Of Proteolysis Response To Stress Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Stability Regulation Of Proteasomal Protein Catabolic Process PML Body Positive Regulation Of Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Symbiont-mediated Disruption Of Host Cell PML Body Cellular Response To Actinomycin D Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle Regulation Of Cell Population Proliferation Response To Actinomycin D Intracellular Signal Transduction Cellular Response To UV-C Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Regulation Of Biological Quality Positive Regulation Of Proteolysis Negative Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Negative Regulation Of Signal Transduction P53 Binding Programmed Cell Death Protein Stabilization Cell Death Regulation Of Cellular Response To Stress Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Antibiotic Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Rhythmic Process Cytosol Cellular Response To Stress Signal Transduction Response To UV-C Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Negative Regulation Of Protein Catabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Cell Population Proliferation Circadian Behavior Negative Regulation Of Catabolic Process	Presynaptic Cytosol Protein Tag Activity Protein Sumoylation Postsynaptic Cytosol Nucleus Post-translational Protein Modification Protein Modification By Small Protein Conjugation PML Body Protein Poly-ADP-ribosylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Ubiquitin-like Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Small Protein Activating Enzyme Binding Positive Regulation Of Telomere Capping Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Glutamatergic Synapse Modification-dependent Protein Catabolic Process Protein Metabolic Process Protein Localization To Chromosome, Telomeric Region Protein Auto-ADP-ribosylation NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity Regulation Of Telomere Capping Protein Localization To Organelle Cytoplasm Positive Regulation Of Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Cytosol Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Proteasome Binding Negative Regulation Of DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin-specific Protease Binding Cellular Response To Cadmium Ion SUMO Transferase Activity Transcription Factor Binding Nuclear Pore NAD+-protein Mono-ADP-ribosyltransferase Activity Positive Regulation Of Type I Interferon Production Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Pericentriolar Material Positive Regulation Of Telomere Maintenance Via Telomerase Response To Cytokine
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