TOR1AIP1 and KIFAP3

		TOR1AIP1	KIFAP3
Description		torsin 1A interacting protein 1	kinesin associated protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Endomembrane System Membrane Nuclear Membrane	Condensed Nuclear Chromosome Photoreceptor Outer Segment Photoreceptor Inner Segment Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Kinesin Complex Spindle Microtubule Cilium Axoneme Microtubule Cytoskeleton Kinesin II Complex Photoreceptor Connecting Cilium Dendrite Cytoplasm Ciliary Transition Zone Ciliary Basal Body Ciliary Tip Postsynapse Glutamatergic Synapse Periciliary Membrane Compartment
	Molecular Function	ATPase Activator Activity Protein Binding Lamin Binding Cytoskeletal Protein Binding ATPase Binding	Protein Binding Kinesin Binding Protein Phosphatase Binding Intraciliary Transport Particle B Binding
	Biological Process	Positive Regulation Of ATP-dependent Activity Protein Localization To Nucleus Nuclear Membrane Organization Protein Localization To Nuclear Envelope	Apoptotic Process Microtubule-based Process Microtubule-based Movement Signal Transduction Neuroblast Proliferation Negative Regulation Of Neuroblast Proliferation Intracellular Protein Localization Cell Population Proliferation Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Apoptotic Process Cilium Organization Positive Regulation Of Calcium-dependent Cell-cell Adhesion Protein-containing Complex Assembly Thymocyte Apoptotic Process Negative Regulation Of Thymocyte Apoptotic Process Plus-end-directed Vesicle Transport Along Microtubule Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex
Pathways		RHOD GTPase cycle RHOF GTPase cycle	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Acute anterior uveitis in ankylosing spondylitis ( 32492107) Adverse response to drug ( 30420678) Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 28416818) L-selectin levels ( 25576479) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: CDC42 LMNA LMNB1 OGT PPP1CA PPP1CC TERF2 TERF2IP	33 interacting genes: APC AR C19orf44 CCSER2 DHX37 DISC1 GTSE1 HOXB5 KANK2 KIF3B MAP3K10 MAP3K11 MARK2 MEST MINK1 MOS MYPOP NAA10 NAA11 NAV1 NCF2 NIPSNAP3A NUDT21 PARD6G PEX19 PRNP RAP1GDS1 RBFOX1 RBM14 RPGR RTP5 SMC3 SRC
Entrez ID		26092	22920
HPRD ID		13958	03499
Ensembl ID		ENSG00000143337	ENSG00000075945
Uniprot IDs		Q5JTV8	A0AAQ5BGI3 Q92845
PDB IDs		4TVS
Enriched GO Terms of Interacting Partners?		Telomere Maintenance In Response To DNA Damage Organelle Organization Structural Constituent Of Nuclear Lamina Negative Regulation Of DNA Recombination At Telomere Nuclear Migration Nucleus Localization Chromosome, Telomeric Region Lamin Filament Nuclear Pore Localization Shelterin Complex Postsynapse Circadian Regulation Of Gene Expression PTW/PP1 Phosphatase Complex Protection From Non-homologous End Joining At Telomere Glutamatergic Synapse Intracellular Protein Localization Establishment Of Organelle Localization Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Protein Localization To Organelle Protein Localization To Chromosome, Telomeric Region Telomere Capping Negative Regulation Of Cellular Component Organization Nuclear Lamina Telomere Maintenance Protein Localization To Nuclear Envelope Regulation Of Telomere Maintenance Chromosome Organization Telomere Organization Circadian Rhythm Nuclear Envelope Organization Entrainment Of Circadian Clock By Photoperiod Protein Phosphatase 1 Binding RNA-templated DNA Biosynthetic Process Organelle Localization Transport Along Microtubule Photoperiodism Entrainment Of Circadian Clock Telomeric DNA Binding Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Telomere Maintenance Microtubule-based Transport Intracellular Transport Regulation Of Chromosome Organization Rhythmic Process Negative Regulation Of DNA Recombination Male Germ Cell Nucleus Glycogen Metabolic Process Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Recombination	Microtubule-based Process Protein Autophosphorylation Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Cytoplasm Organelle Organization MAP Kinase Kinase Kinase Activity Protein N-terminal-serine Acetyltransferase Activity Cytoskeleton Organization ATPase Binding Microtubule Cytoskeleton Organization NatA Complex Microtubule Regulation Of Intracellular Estrogen Receptor Signaling Pathway Protein-N-terminal Amino-acid Acetyltransferase Activity MAPK Cascade Regulation Of Protein Serine/threonine Kinase Activity Microtubule Binding Microtubule Cytoskeleton JUN Kinase Kinase Kinase Activity Negative Regulation Of Cell Cycle Process Membraneless Organelle Assembly Positive Regulation Of Protein Serine/threonine Kinase Activity Centrosome Positive Regulation Of MAPK Cascade JNK Cascade Positive Regulation Of JUN Kinase Activity N-terminal Protein Amino Acid Acetylation Regulation Of MAPK Cascade Protein Binding Cytoskeleton Organelle Assembly Protein Kinase Activity Intracellular Signal Transduction Lamin Binding Negative Regulation Of Chromosome Organization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphorylation Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Angiotensin-activated Signaling Pathway Dynein Complex Binding Mitochondrial Calcium Ion Homeostasis Phosphorylation Protein Serine/threonine Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Protein Kinase Activity ATP Binding Kinase Activity Regulation Of Chromosome Organization
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