GAP43 and PLCD1

Number of citations of the paper that reports this interaction (PubMedID 12805215)
45

Data Source:
HPRD (in vivo)

		GAP43	PLCD1
Description		growth associated protein 43	phospholipase C delta 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Axon Dendrite Filopodium Membrane Growth Cone Membrane Cell Projection Perikaryon Synapse Cell Periphery Presynapse GABA-ergic Synapse	Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Protein Binding Calmodulin Binding Lysophosphatidic Acid Binding Phosphatidylinositol Phosphate Binding	Phosphatidylserine Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity GTPase Activating Protein Binding Anion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol Phospholipase C Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Nervous System Development Axon Guidance Response To Wounding Response To Auditory Stimulus Axon Choice Point Recognition Cell Differentiation Axon Regeneration Regulation Of Growth Tissue Regeneration Cell Fate Commitment Astrocyte Differentiation Regulation Of Filopodium Assembly Radial Glial Cell Differentiation Regulation Of Postsynaptic Specialization Assembly	Lipid Metabolic Process Phospholipid Metabolic Process Signal Transduction Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phospholipase C/protein Kinase C Signal Transduction
Pathways		L1CAM interactions	Synthesis of IP3 and IP4 in the cytosol
Drugs			1D-myo-inositol 1,4,5-trisphosphate Inositol 2,4,5-trisphosphate
Diseases
GWAS		Borderline personality disorder ( 28632202) Breast size ( 22747683) Metabolite levels ( 23823483) Proliferative diabetic retinopathy ( 31482010) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Seasonality and depression ( 30217971) Urate levels in obese individuals ( 25811787)
Interacting Genes		8 interacting genes: CALM1 CSNK2A1 ELAVL4 PLCD1 PRKCB PRKCD RABEP1 SPTAN1	10 interacting genes: APP CALM1 GAP43 HGS KPNB1 NTAQ1 PAXIP1 RALA RALB TGM2
Entrez ID		2596	5333
HPRD ID		01198	09073
Ensembl ID		ENSG00000172020	ENSG00000187091
Uniprot IDs		P17677 Q5U058	A0A384MR47 A8K8F9 P51178
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase C Signaling Phospholipase C/protein Kinase C Signal Transduction Spectrin Diacylglycerol-dependent Serine/threonine Kinase Activity Calyx Of Held Cell Death Apoptotic Process Programmed Cell Death Presynaptic Cytosol Regulation Of Biological Quality Calcium Channel Regulator Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Organization Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Actin Filament Polymerization Descending Aorta Development Ascending Aorta Development Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Regulation Of Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cellular Response To Interleukin-12 Protein Serine Kinase Activity Pre-mRNA Intronic Pyrimidine-rich Binding Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Histone H3T6 Kinase Activity Positive Regulation Of Sphingomyelin Catabolic Process Regulation Of Supramolecular Fiber Organization Negative Regulation Of Transport Response To Type II Interferon Cellular Response To Cytokine Stimulus Protein Kinase CK2 Complex Protein Serine/threonine Kinase Activity Symbiont-mediated Disruption Of Host Cell PML Body Peptidyl-lysine Oxidation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Intracellular Signal Transduction Negative Regulation Of Transmembrane Transport Protein Binding Involved In Heterotypic Cell-cell Adhesion	Endocytosis Import Into Cell Axon Choice Point Recognition Receptor Internalization Vesicle-mediated Transport Response To Auditory Stimulus Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Receptor-mediated Endocytosis Positive Regulation Of ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Filopodium Assembly Regulation Of Exocyst Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Synaptic Membrane Acetylcholine Receptor Activator Activity Regulation Of Signal Transduction G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Regulation Of Receptor Internalization Positive Regulation Of Protein Import Signal Transduction Extracellular Exosome Regulation Of Endocytosis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Organelle ATPase Binding GDP Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Edg-2 Lysophosphatidic Acid Receptor Binding G Protein Activity
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